JAML Activators
JAML Activators are a class of chemical compounds that enhance the functional activity of JAML, a protein known for its role in cell adhesion and immune response. Some JAML activators, such as LFA-1 Activator, PMA, and Sodium orthovanadate, directly influence JAML's interactions or post-translational modifications. PMA, a PKC activator, enhances JAML activity by promoting PKC-dependent phosphorylation of JAML. Sodium orthovanadate, a phosphatase inhibitor, enhances JAML activity by preventing dephosphorylation of JAML.
Other JAML activators function by impacting the cellular signaling pathways involved in the regulation of JAML. For instance, PGE2, Forskolin, and PIP2 activate pathways that lead to the upregulation of JAML. PGE2 activates EP2 and EP4 receptors, Forskolin activates adenylate cyclase, and PIP2 activates phospholipase C. Eachof these activations results in the production of second messengers known to upregulate JAML. Similarly, Ionomycin, Anandamide, Acetylcholine, and Epinephrine enhance JAML activity by promoting the influx of calcium or activating receptors that upregulate JAML. Ionomycin increases intracellular calcium, a known cofactor for JAML activation. Anandamide and Acetylcholine activate cannabinoid and muscarinic acetylcholine receptors, respectively, which are known to upregulate JAML. Epinephrine enhances JAML activity by activating beta-adrenergic receptors, which have been associated with JAML upregulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator. PKC is known to phosphorylate JAML, leading to its activation. By activating PKC, PMA can enhance the functional activity of JAML. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is known to activate EP2 and EP4 receptors, which are known to upregulate JAML via a cAMP-dependent pathway. By activating these receptors, PGE2 can enhance the functional activity of JAML. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cAMP levels. cAMP is known to upregulate JAML, and by increasing cAMP, Forskolin can enhance the functional activity of JAML. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore. Calcium is known to be a cofactor for the activation of JAML, and by increasing intracellular calcium, Ionomycin can enhance the functional activity of JAML. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a phosphatase inhibitor. Phosphatases are known to dephosphorylate JAML, and by inhibiting their activity, Sodium orthovanadate can enhance the functional activity of JAML. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
LTB4 is known to bind to the BLT1 receptor, which can lead to the enhancement of JAML activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is known to bind to beta-adrenergic receptors, which are known to upregulate JAML. By activating these receptors, Epinephrine can enhance the functional activity of JAML. | ||||||