Date published: 2026-5-1

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ISG20 Inhibitors

The chemical class known as ISG20 inhibitors comprises a diverse group of organic molecules distinguished by their unique molecular structures and their ability to interact with specific components of the ISG20 gene or its associated proteins. ISG20, or Interferon Stimulated Gene 20, encodes an exonuclease enzyme that participates in RNA degradation and immune responses. The development of ISG20 inhibitors is rooted in a comprehensive understanding of the intricate molecular mechanisms involving this gene, which plays a crucial role in cellular and immune processes. ISG20 inhibitors are meticulously designed through a combination of rational drug design strategies and empirical experimentation. Researchers employ advanced techniques to engineer the structural attributes of these inhibitors, enabling them to selectively bind to specific regions of ISG20 or its interacting partners. This selective binding ability allows ISG20 inhibitors to interfere with the enzymatic activities of ISG20, thereby influencing the intricate molecular pathways that ISG20 regulates.

The chemical structures of ISG20 inhibitors exhibit a notable diversity, reflecting the complexity of ISG20 and its multifaceted interactions within cellular pathways. The design of ISG20 inhibitors is informed by insights from structural biology, computational modeling, and detailed biochemical analysis. By scrutinizing the molecular interactions involving ISG20, researchers can strategically engineer inhibitors with tailored properties to selectively disrupt ISG20-associated processes. ISG20 inhibitors hold significant promise as indispensable tools for advancing scientific understanding of ISG20's role. By perturbing ISG20-mediated pathways, these inhibitors offer researchers a means to unravel the complex web of molecular events that underlie cellular functions and immune responses. The development of ISG20 inhibitors exemplifies the ongoing commitment to uncovering the nuanced contributions of ISG20 to cellular and immune regulation. As research progresses, elucidating the effects of ISG20 inhibitors continues to provide profound insights into the intricate molecular orchestration that governs cellular behavi

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ribavirin

36791-04-5sc-203238
sc-203238A
sc-203238B
10 mg
100 mg
5 g
$63.00
$110.00
$214.00
1
(1)

Although primarily known as an antiviral drug, ribavirin has been investigated for its inhibitory effects on ISG20 due to its ability to interfere with RNA metabolism and viral replication.

NSC 185058

39122-38-8sc-507531
1 mg
$85.00
(0)

This compound has been identified as an ISG20 inhibitor and is thought to interfere with the enzymatic activity of ISG20, potentially affecting its RNA degradation function.

Isoginkgetin

548-19-6sc-507430
5 mg
$225.00
(0)

Isoginkgetin is a natural compound that has been explored for its inhibitory effects on ISGIt may interfere with the exonuclease activity of ISG20.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

This short-chain fatty acid has been investigated for its potential to inhibit ISG20 expression and activity, possibly modulating its effects on antiviral immune responses.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$151.00
104
(1)

Although primarily known as a STAT3 inhibitor, S3I-201 has been reported to inhibit ISG20 expression. It interferes with the STAT3-mediated transcription of ISG20, influencing its activity.

Apilimod

541550-19-0sc-480051
sc-480051A
100 mg
1 g
$428.00
$2652.00
5
(0)

STA-5326 is an inhibitor that has been associated with modulating immune responses. It may have effects on ISG20 as part of its broader immunomodulatory properties.

PKR Inhibitor

608512-97-6sc-204200C
sc-204200
sc-204200D
sc-204200E
sc-204200A
sc-204200B
1 mg
5 mg
10 mg
25 mg
50 mg
100 mg
$65.00
$153.00
$306.00
$612.00
$816.00
$1836.00
5
(1)

C16 is a ceramide analog that has shown potential in inhibiting ISGIts effects on ISG20 may contribute to its broader influence on cellular processes.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$98.00
$255.00
$765.00
$1457.00
280
(6)

Although recognized as an autophagy inhibitor, Bafilomycin A1 has been reported to suppress ISG20 expression. Its impact on ISG20 could have implications for immune responses and RNA degradation.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Primarily known as an antimalarial drug, Chloroquine has demonstrated inhibitory effects on ISG20 expression. Its modulation of ISG20 could contribute to its diverse biological effects.

Dihydro Artemisinin

71939-50-9sc-211332
100 mg
$233.00
1
(1)

Dihydroartemisinin, an antimalarial compound, has been linked to inhibiting ISG20 expression. Its influence on ISG20 could contribute to its antiparasitic and immunomodulatory effects.