IscU2 Inhibitors
IscU2 inhibitors represent a diverse array of chemicals designed to modulate IscU2, a crucial player in iron-sulfur cluster biogenesis. These inhibitors can be broadly classified into direct and indirect inhibitors, each offering unique insights into the complex processes governing cellular iron homeostasis. Direct inhibitors, such as TPEN, NEM, and Dp44mT, operate by interfering with IscU2's metal-binding sites, disrupting its catalytic activity essential for iron-sulfur cluster assembly. TPEN, a metal chelator, sequesters metal ions critical for IscU2 function, impacting cellular processes dependent on proper iron-sulfur cluster biogenesis. N-Ethylmaleimide (NEM) induces thiol alkylation, modifying cysteine residues crucial for IscU2, thus interfering with iron-sulfur cluster coordination. Dp44mT, another metal chelator, disrupts IscU2's catalytic activity by sequestering metal ions, providing a targeted approach for investigating the intricacies of iron-sulfur cluster biogenesis.
Indirect inhibitors, including Deferoxamine, Bipyridyl, and Deferasirox, reduce the availability of iron for IscU2-mediated iron-sulfur cluster assembly. These metal chelators sequester iron, impairing IscU2's role in coordinating iron-sulfur clusters and affecting downstream cellular processes reliant on functional iron-sulfur proteins. Electrophilic compounds like Methylglyoxal modify specific amino acid residues on IscU2, impacting its structural integrity and inhibiting iron-sulfur cluster assembly. The diverse mechanisms of IscU2 inhibition offer a comprehensive toolkit for researchers to delve into the intricate roles of IscU2 in cellular iron homeostasis. These inhibitors contribute to understanding the molecular underpinnings of IscU2 function. As research in this field advances, the detailed characterization of IscU2 inhibitors provides a foundation for uncovering novel insights into cellular metal homeostasis and its implications for human health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TPEN | 16858-02-9 | sc-200131 | 100 mg | $127.00 | 10 | |
TPEN (N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine) is a metal chelator that indirectly influences IscU2 by sequestering metal ions essential for its function. It disrupts iron-sulfur cluster formation, affecting the catalytic activity of IscU2 involved in iron-sulfur cluster assembly. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $250.00 | ||
Deferoxamine is an iron chelator that indirectly modulates IscU2 by reducing the availability of iron for iron-sulfur cluster assembly. By sequestering iron, Deferoxamine impairs the function of IscU2 in facilitating iron-sulfur cluster biogenesis. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide (NEM) acts as a thiol-reactive compound, indirectly influencing IscU2 by modifying cysteine residues critical for its function. Through thiol alkylation, NEM disrupts the thiol-dependent interactions involved in IscU2-mediated iron-sulfur cluster assembly. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $143.00 $428.00 $469.00 $739.00 $1418.00 | 3 | |
Methylglyoxal is an electrophilic compound that indirectly influences IscU2 by forming advanced glycation end products (AGEs) on lysine residues crucial for its function. AGE formation disrupts the structural integrity of IscU2, impairing its catalytic activity in iron-sulfur cluster assembly. | ||||||
Iron Chelator, Dp44mT | 152095-12-0 | sc-221764 | 25 mg | $204.00 | ||
Dp44mT is a metal chelator that indirectly affects IscU2 by sequestering metal ions essential for iron-sulfur cluster assembly. Through metal chelation, Dp44mT disrupts the catalytic activity of IscU2, influencing cellular processes reliant on functional iron-sulfur proteins. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $176.00 | 9 | |
Deferasirox is an iron chelator that indirectly modulates IscU2 by reducing the availability of iron for iron-sulfur cluster assembly. By sequestering iron, Deferasirox impairs the function of IscU2 in facilitating iron-sulfur cluster biogenesis. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
Pyrrolidine Dithiocarbamate (PDTC) acts as a metal chelator that indirectly influences IscU2 by sequestering metal ions crucial for its function in iron-sulfur cluster assembly. PDTC disrupts the catalytic activity of IscU2, impacting cellular processes reliant on functional iron-sulfur proteins. | ||||||
Deferiprone | 30652-11-0 | sc-211220 sc-211220A | 1 g 5 g | $122.00 $131.00 | 5 | |
Deferiprone is an iron chelator that indirectly modulates IscU2 by reducing the availability of iron for iron-sulfur cluster assembly. By sequestering iron, Deferiprone impairs the function of IscU2 in facilitating iron-sulfur cluster biogenesis. | ||||||