IscU2 Activators
IscU2 activators are compounds specifically designed to enhance or stimulate the activity of the IscU2 protein or its associated pathway. These chemical agents can function through a variety of mechanisms, often depending on the precise role of IscU2 within the cell. Direct activators are molecules that bind to IscU2, either at its primary active site or at allosteric regions. Such binding events can trigger conformational changes in the protein, thus enhancing its activity or promoting its interaction with other molecular partners. In some instances, this direct binding can prevent inhibitory molecules from interacting with IscU2, thus providing a form of activation by preventing deactivation.
One category of IscU2 activators includes reducing agents such as DTT and glutathione. These compounds can potentially act as direct activators by providing thiol groups, enhancing the stability and functionality of IscU2 in facilitating iron-sulfur cluster assembly. Additionally, chelating agents like 2,3-dimercaptopropanol can directly influence the metal cofactor environment of IscU2, potentially enhancing its role in iron-sulfur cluster biogenesis. Indirect activators of IscU2 include compounds like ferric citrate, lipoic acid, and sulfur. Ferric citrate serves as a source of iron, indirectly impacting IscU2 by influencing iron homeostasis. Lipoic acid, involved in mitochondrial metabolism, may indirectly activate IscU2 by participating in redox reactions and influencing pathways associated with iron-sulfur cluster assembly. Elemental sulfur, as another indirect activator, serves as a precursor for sulfur-containing compounds crucial for IscU2 function. Furthermore, compounds like Nifedipine and sodium nitroprusside can influence cellular signaling pathways, indirectly affecting IscU2 expression or activity in the context of iron-sulfur cluster biogenesis. In summary, the diverse IscU2 activators exert their effects through various mechanisms, either directly enhancing IscU2 stability or indirectly influencing pathways associated with iron-sulfur cluster biogenesis. Understanding the intricate interplay between these chemicals and IscU2 provides valuable insights into the regulation of cellular processes related to iron-sulfur cluster assembly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iron(III) citrate | 3522-50-7 | sc-286019 sc-286019A | 100 g 250 g | $45.00 $85.00 | ||
Ferric citrate, a source of iron, may indirectly activate IscU2 by influencing iron homeostasis. Iron is a crucial cofactor for IscU2 function, and supplementation with ferric citrate could potentially enhance iron availability, leading to increased IscU2 activity and its involvement in iron-sulfur cluster assembly. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid is involved in mitochondrial energy metabolism and may act as an indirect activator of IscU2. By participating in redox reactions and serving as a cofactor, lipoic acid could influence cellular pathways associated with IscU2, potentially enhancing its expression or activity in the context of iron-sulfur cluster biogenesis. | ||||||
Sulfur | 7704-34-9 | sc-215933 sc-215933A | 500 g 2 kg | $51.00 $158.00 | ||
Elemental sulfur may serve as a precursor for sulfur-containing compounds involved in iron-sulfur cluster biogenesis. As a potential indirect activator of IscU2, sulfur contributes to the cellular pool of sulfur, influencing pathways related to IscU2 function and promoting the assembly of iron-sulfur clusters. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a calcium channel blocker, may indirectly impact IscU2 by modulating calcium-dependent signaling pathways. Calcium signaling is implicated in various cellular processes, and Nifedipine could potentially influence these pathways, indirectly affecting IscU2 activity in the context of iron-sulfur cluster biogenesis. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione, a tripeptide thiol, may act as a direct or indirect activator of IscU2. As a reducing agent, glutathione can potentially enhance the stability and functionality of IscU2 by providing thiol groups. Additionally, glutathione may influence cellular redox status, indirectly impacting IscU2 activity and its role in iron-sulfur cluster biogenesis. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
Citric acid, a tricarboxylic acid, may indirectly activate IscU2 by participating in cellular metabolic pathways. As a component of the citric acid cycle, citric acid influences various metabolic processes, potentially affecting IscU2 expression or activity in the context of iron-sulfur cluster biogenesis. | ||||||
NADH disodium salt | 606-68-8 | sc-205762 sc-205762A | 500 mg 1 g | $89.00 $127.00 | 3 | |
NADH, a coenzyme involved in redox reactions, may act as a direct or indirect activator of IscU2. By participating in cellular redox processes, NADH could directly influence IscU2 function or indirectly impact its activity by modulating cellular redox status, thereby affecting iron-sulfur cluster biogenesis. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Sodium nitroferricyanide, a nitric oxide donor, may indirectly activate IscU2 by influencing cellular signaling pathways. Nitric oxide is involved in various cellular processes, and sodium nitroprusside could potentially modulate these pathways, indirectly affecting IscU2 expression or activity in the context of iron-sulfur cluster biogenesis. | ||||||
Ammonium Sulfate | 7783-20-2 | sc-29085A sc-29085 sc-29085B sc-29085C sc-29085D sc-29085E | 500 g 1 kg 2 kg 5 kg 10 kg 22.95 kg | $10.00 $20.00 $30.00 $40.00 $60.00 $100.00 | 9 | |
Ammonium sulfate, a source of ammonium ions, may act as a potential indirect activator of IscU2. Ammonium ions are involved in nitrogen metabolism and could influence cellular pathways associated with IscU2, indirectly impacting its expression or activity in the context of iron-sulfur cluster biogenesis. | ||||||