IRX3 Activators
IRX3 activators comprise a diverse group of chemicals that influence the activity or expression of the Iroquois Homeobox 3 (IRX3) protein, either directly or indirectly. This variety is due to IRX3's role as a transcription factor involved in numerous developmental and cellular processes. Direct activators specifically target IRX3, enhancing its transcriptional activity or stabilizing its expression. However, due to the complexity of transcription factor regulation and the current state of research, specific direct activators of IRX3 are not widely recognized or established.
Indirect activators, on the other hand, influence IRX3 by modulating various signaling pathways and cellular mechanisms that converge on its regulation. For example, Forskolin raises cAMP levels, which can lead to changes in gene expression patterns, including those of IRX3. Retinoic Acid, a vital regulator in development, affects IRX3 by altering the transcriptional landscape of retinoic acid-responsive genes. Similarly, agents like 5-Azacytidine and Histone Deacetylase Inhibitors modulate epigenetic marks, thereby potentially influencing IRX3 expression. Beta-Catenin, AMPK, PI3K, and mTOR activators function by modulating their respective pathways, all of which can have downstream effects on IRX3's role in cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can indirectly upregulate IRX3 expression by altering DNA methylation patterns. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
These inhibitors, like Trichostatin A, can indirectly enhance IRX3 expression by modifying chromatin structure and affecting gene transcription. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Beta-Catenin activators like BIO can indirectly influence IRX3 activity by modulating the Wnt signaling pathway, which may affect IRX3. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AMPK activators such as AICAR can indirectly modulate IRX3 expression by altering cellular energy homeostasis and metabolic pathways. | ||||||
MHY1485 | 326914-06-1 | sc-507522 | 10 mg | $140.00 | ||
mTOR activators like MHY1485 can indirectly modulate IRX3 expression by affecting protein synthesis and cellular growth pathways. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen receptor agonists like Estradiol can indirectly influence IRX3 activity by modulating estrogen-responsive pathways. | ||||||