IRX2 Activators
The class of chemicals known as IRX2 Activators primarily involves modulators of the retinoic acid receptors (RARs) and retinoid X receptors ((RXRs). These receptors are directly related to the retinoic acid signaling pathway, which is critical for cellular growth, differentiation, and development. These compounds, including retinoic acid and its various isoforms (ATRA, 9-cis-retinoic acid, 13-cis-retinoic acid), synthetic retinoids (Am80, TTNPB, Adapalene, Tazarotene, CD 437), and specific antagonists of RAR (AGN 193109, Ro 41-5253, CD 2665), can all trigger gene transcription events that lead to activation of the IRX2 protein directly or indirectly. They accomplish this by binding to and modulating the activity of RAR and RXR receptors.
When these compounds bind to RAR and RXR receptors, they cause changes in the conformation of the receptors, allowing them to dimerize and act as transcription factors. These transcription factors then regulate the expression of a variety of genes involved in cellular growth and differentiation. This process is critical for the functional activity of IRX2, as the protein is directly involved in retinoic acid-induced differentiation and heart development. Therefore, through the activation and modulation of the retinoic acid signaling pathway, these compounds can enhance the functional activity of IRX2. This enhancement is not achieved through direct interaction with the IRX2 protein, but rather through the activation of specific signaling pathways and biological processes that IRX2 is directly involved in.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that mediates the functions of vitamin A required for growth and development. Retinoic acid binds to and activates retinoic acid receptor (RAR) and retinoid X receptor (RXR) which regulate gene transcription. Activation of these receptors can induce the expression of IRX2, as it's known that retinoic acid signaling plays a crucial role in heart development, a biological process that IRX2 is directly involved in. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-retinoic acid is a form of vitamin A that binds to and activates both RAR and RXR receptors. Activation of these receptors triggers gene transcription, which can enhance IRX2 activity given its role in retinoic acid-induced differentiation and heart development. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
13-cis-retinoic acid is an agent in research primarily used to treat severe acne. It is a retinoid, meaning it is found in vitamin A, and works by activating RAR and RXR receptors. This activation can indirectly enhance IRX2 activity, as IRX2 is directly involved in retinoic acid-induced differentiation and heart development. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
Am80 is a synthetic retinoid with selective activity for RARα and RARβ. It can enhance the activation of IRX2 by triggering gene transcription via RARα/β activation, given that IRX2 is known to be involved in retinoic acid-induced differentiation and heart development. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $66.00 $332.00 | 2 | |
Adapalene is a topical retinoid primarily studied in the research of acne. It binds to specific retinoic acid nuclear receptors, which can indirectly enhance IRX2 activity given its role in retinoic acid-induced differentiation and heart development. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene is a synthetic retinoid. It binds to all three RAR receptors, which then alter gene expression. This can indirectly enhance IRX2 activity, as IRX2 is known to be involved in retinoic acid-induced differentiation and heart development. | ||||||
CD 2665 | 170355-78-9 | sc-293988 sc-293988A | 10 mg 50 mg | $360.00 $1400.00 | 2 | |
CD 2665 is a selective RARα antagonist. By inhibiting RARα, it can modulate gene transcription enhancing IRX2 activity indirectly, as IRX2 is involved in retinoic acid-induced differentiation and heart development. | ||||||
CD 437 | 125316-60-1 | sc-202527 | 5 mg | $121.00 | ||
CD 437 is a synthetic retinoid that selectively activates RARγ. By activating RARγ, it can modulate gene transcription enhancing IRX2 activity indirectly, as IRX2 is involved in retinoic acid-induced differentiation and heart development. | ||||||