Date published: 2025-11-22

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CD 2665 (CAS 170355-78-9)

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Alternate Names:
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic acid
Application:
CD 2665 is a selective RARβ/γ antagonist
CAS Number:
170355-78-9
Purity:
>98%
Molecular Weight:
486.60
Molecular Formula:
C31H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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CD 2665 is a synthetic compound of interest in the field of dermatological research, where it is used to study the regulation of retinoid-responsive genes. As an agonist of the retinoic acid receptors (RARs), it aids in dissecting the pathways through which retinoids impact cellular differentiation and proliferation. In vitro studies harness CD 2665 to observe changes in skin cell morphology and to analyze gene expression profiles in response to retinoic acid receptor activation. Furthermore, this compound provides a means to explore the signaling mechanisms that are involved in the homeostasis of skin tissue. Additionally, CD 2665′s role in modulating retinoid pathways makes it useful in research targeted at understanding the molecular basis of skin development and the potential disruptions that can lead to various skin conditions.


CD 2665 (CAS 170355-78-9) References

  1. The role of specific retinoid receptors in sebocyte growth and differentiation in culture.  |  Kim, MJ., et al. 2000. J Invest Dermatol. 114: 349-53. PMID: 10651997
  2. Differential effects of several retinoid receptor-selective ligands on squamous differentiation and apoptosis in airway epithelial cells.  |  Boisvieux-Ulrich, E., et al. 2000. Cell Tissue Res. 300: 67-81. PMID: 10805076
  3. Activation of retinoic acid receptor gamma induces proliferation of immortalized hippocampal progenitor cells.  |  Chung, JJ., et al. 2000. Brain Res Mol Brain Res. 83: 52-62. PMID: 11072095
  4. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice.  |  Alfos, S., et al. 2001. Alcohol Clin Exp Res. 25: 1506-14. PMID: 11696672
  5. All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells.  |  Xu, Y., et al. 2010. Tumour Biol. 31: 589-95. PMID: 20632143
  6. Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro.  |  Sato, T., et al. 2013. J Dermatol Sci. 70: 204-10. PMID: 23473858
  7. Retinol but not retinoic acid can enhance the glutathione level, in a manner similar to β-carotene, in a murine cultured macrophage cell line.  |  Mukai, Y. and Yamanishi, R. 2018. Food Sci Nutr. 6: 1650-1656. PMID: 30258608
  8. Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations.  |  le Maire, A., et al. 2019. Cells. 8: PMID: 31694317
  9. Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice.  |  Koyama, E., et al. 2021. J Bone Miner Res. 36: 1387-1402. PMID: 33724538
  10. Augmented Therapeutic Potential of EC-Synthetic Retinoids in Caco-2 Cancer Cells Using an In Vitro Approach.  |  Abdelaal, MR., et al. 2022. Int J Mol Sci. 23: PMID: 36012706
  11. Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437.  |  Sun, SY., et al. 1997. J Cell Physiol. 173: 279-84. PMID: 9365537
  12. Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma.  |  Meister, B., et al. 1998. Anticancer Res. 18: 1777-86. PMID: 9673404
  13. Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells.  |  Marikar, Y., et al. 1998. J Invest Dermatol. 111: 434-9. PMID: 9740237

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CD 2665, 10 mg

sc-293988
10 mg
$238.00
US: Only available in the US

CD 2665, 50 mg

sc-293988A
50 mg
$974.00
US: Only available in the US