IQCC Activators
The chemical class referred to as IQCC Activators comprises compounds that possess the capability to enhance the activity or modulate the function of IQCC or proteins containing IQ motifs. These activators operate through various mechanisms primarily centered around the regulation of calcium signaling and the modulation of calmodulin activity. IQ motifs within the protein have a notable affinity for binding calmodulin, making this interaction pivotal in IQCC-mediated cellular processes.
IQCC activators are envisioned as compounds that can effectively promote IQCC's activity or modulate its function. These compounds may facilitate the binding of calmodulin to IQ motifs, leading to the activation of downstream signaling cascades. By augmenting calcium-mediated interactions, IQCC activators have the to enhance the protein's role in cellular processes that rely on precise calcium-dependent regulation. Additionally, IQCC activators can modulate calmodulin activity, indirectly impacting IQCC function by fine-tuning its interaction with the calmodulin-IQ motif complex.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
EGTA is a chelating agent that sequesters calcium ions, reducing the availability of calcium for binding to calmodulin and influencing IQCC-mediated signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA is a calcium chelator that disrupts calcium-calmodulin interactions and downstream signaling pathways involving IQ motifs. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that reduces intracellular calcium levels, potentially affecting calmodulin-mediated signaling pathways involving IQ motifs. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates calcium release from the sarcoplasmic reticulum, impacting intracellular calcium levels and calmodulin signaling in IQCC-containing proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts intracellular calcium homeostasis by inhibiting the SERCA pump, indirectly affecting IQ motif-mediated signaling pathways. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 inhibits calcium/calmodulin-dependent protein kinase II (CaMKII), a downstream target of calmodulin, modulating IQCC-related signaling pathways. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Lanthanides, such as lanthanum chloride, inhibit calcium influx through ion channels, indirectly affecting calmodulin-mediated signaling pathways involving IQ motifs. | ||||||