INTS5 Inhibitors
Chemical inhibitors of INTS5 can interfere with its function in various cellular processes by targeting different mechanisms within the cell. Paclitaxel, by stabilizing microtubules, can disrupt cell cycle progression, which in turn can lead to an inhibition of INTS5 since its function is cell cycle-dependent. Oligomycin A affects INTS5 by inhibiting mitochondrial ATP synthase, thus reducing the levels of ATP necessary for the energy-dependent processes in which INTS5 is involved. Similarly, Brefeldin A can impede INTS5's role by disrupting the transport between the endoplasmic reticulum and the Golgi apparatus, potentially leading to a mislocalization of INTS5 or its substrates. Camptothecin and Etoposide, both targeting topoisomerases, can indirectly inhibit INTS5 by interfering with DNA replication and transcription, reducing the availability of mRNA substrates needed for processing.
On another front, Cycloheximide, by inhibiting protein synthesis, can affect INTS5 indirectly due to the reduced availability of substrate proteins that INTS5 would typically process. Leptomycin B works by inhibiting nuclear export, which can have a direct impact on INTS5's function within the nucleus in mRNA processing. Mitomycin C's role in forming DNA adducts can affect transcription, thus affecting INTS5's ability to process mRNA. Actinomycin D prevents transcription by RNA polymerase, leading to a direct decrease in INTS5's RNA substrates. Pertussis Toxin alters cellular signaling pathways, which can affect the regulation of INTS5's activity in mRNA processing. Triptolide, by inhibiting RNA polymerase II, reduces gene transcription, subsequently reducing INTS5's involvement in mRNA processing. Lastly, Tunicamycin's inhibition of N-linked glycosylation can affect the folding and functioning of proteins that are necessary for INTS5's role in mRNA processing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is crucial for mitosis and cell division. INTS5 is involved in mRNA processing which is a cell cycle-dependent process; stabilization of microtubules can disrupt cell cycle progression and consequently inhibit INTS5 function. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A inhibits mitochondrial ATP synthase, leading to a reduction in cellular ATP levels. Since INTS5 function requires energy, a lower ATP level can inhibit the functioning of INTS5 by depriving it of the necessary energy for its activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts transport between the endoplasmic reticulum and the Golgi apparatus. INTS5, involved in mRNA processing, may rely on proper cellular trafficking for its function; disruption of trafficking can inhibit the proper localization and function of INTS5. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, causing DNA damage and halting replication and transcription. As INTS5 is involved in mRNA processing, inhibition of transcription can lead to a functional inhibition of INTS5 as its substrates would be diminished. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. Although not directly inhibiting INTS5, by inhibiting overall protein synthesis, it indirectly inhibits INTS5's role in mRNA processing due to lack of substrate proteins. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA breakage during replication and transcription. By causing DNA damage and affecting transcription, etoposide can indirectly inhibit INTS5 function as it relies on transcription for mRNA processing. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits the export of proteins from the nucleus by blocking the nuclear export signal (NES)-mediated transport pathway. INTS5, which has a role in the nucleus for mRNA processing, can be functionally inhibited if its substrates or associated factors are unable to shuttle between the nucleus and cytoplasm. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA adducts and crosslinks, thereby inhibiting DNA replication and transcription. The inhibition of transcription can indirectly inhibit the function of INTS5, as it is implicated in mRNA processing which is dependent on ongoing transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and prevents the transcription by RNA polymerase. This inhibition of transcription would result in reduced mRNA processing by INTS5 since it would not have RNA substrates to process. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin irreversibly inactivates Gi/o proteins, altering cellular signaling. INTS5 is part of a complex involved in mRNA processing which may be regulated by signaling pathways; inactivation of these pathways can lead to functional inhibition of INTS5. | ||||||