Integrin α3 Activators
Common Integrin α3 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, Forskolin CAS 66575-29-9, Genistein CAS 446-72-0 and Staurosporine CAS 62996-74-1.
Integrins are a family of transmembrane receptors that mediate cell-to-cell and cell-to-extracellular matrix (ECM) interactions. They play a critical role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. The integrin family is composed of various alpha (α) and beta (β) subunits that combine to form heterodimeric receptors, each with specific ligand binding properties and cellular functions. One of the notable members of this family is Integrin α3. This protein is a significant component in the formation of the α3β1 integrin heterodimer. The α3β1 integrin primarily interacts with laminins in the ECM, facilitating cellular attachment and mediating signal transduction pathways that influence cell shape, movement, and even fate.
The chemical class of Integrin α3 Activators are molecules that enhance the activity or expression of Integrin α3. These activators can augment the integrin's interaction with its ECM ligands, thereby promoting cell adhesion and the subsequent downstream signaling pathways. By amplifying the signaling processes associated with Integrin α3, these activators can influence a wide range of cellular behaviors governed by integrin-ligand interactions. For instance, by promoting cell-ECM adhesion, these activators could influence processes like cell migration or tissue repair. Furthermore, by modulating the signaling cascades tied to Integrin α3, these activators can impart effects on cell survival, differentiation, and proliferation. As tools for research, Integrin α3 Activators can offer deep insights into the nuances of integrin-mediated cellular behaviors and their broader roles in tissue physiology and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression via the retinoic acid receptor. It may enhance Integrin α3 expression during differentiation processes, especially in epithelial cells transitioning towards a more mesenchymal phenotype. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone can modulate gene expression. It might upregulate Integrin α3 in response to anti-inflammatory or immunosuppressive mechanisms in certain cell types. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which can activate protein kinase A (PKA). PKA activation might influence the transcription of genes, including Integrin α3, especially in contexts of cell adhesion or migration. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein's tyrosine kinase inhibitory activity can affect multiple signaling pathways. This might lead to the upregulation of Integrin α3 in cells undergoing adhesion or signaling modulation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
By inhibiting protein kinases, staurosporine can alter cellular signaling. This might lead to upregulation of Integrin α3 as a compensatory mechanism or in response to altered cell-matrix interactions. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
As a CDK inhibitor, roscovitine affects the cell cycle. This could lead to upregulation of Integrin α3 during specific cell cycle stages, especially in cells preparing for migration or adhesion. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR signaling, rapamycin can modulate protein synthesis. This might upregulate Integrin α3 as part of cellular responses to changes in growth or protein translation signals. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin-induced ER stress might elevate Integrin α3 expression as a cellular response to altered matrix interactions or as a mechanism to enhance cell survival during stress. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibition of PI3K/Akt signaling by LY294002 can modulate multiple cellular responses. This could lead to Integrin α3 upregulation as cells adapt to changes in survival, growth, or adhesion signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
By inhibiting p38 MAPK, SB203580 affects inflammatory responses. This might induce Integrin α3 expression in cells adjusting to altered inflammatory or stress signals. | ||||||