IL-TIF Inhibitors
Chemical inhibitors of IL-TIF engage in a variety of mechanisms to hinder its function, each utilizing a distinct biochemical pathway to impede the protein's activity. For instance, 1,2,3,4,5,6-Hexabromocyclohexane leverages its role as an aryl hydrocarbon receptor agonist to suppress IL-TIF transcription. When it binds to dioxin-responsive elements within the IL-TIF promoter region, it recruits the AhR/ARNT complex, thereby repressing the transcriptional activity necessary for IL-TIF production. Similarly, 4-Octyl itaconate activates the Nrf2 pathway, which indirectly diminishes IL-TIF signaling by promoting anti-inflammatory gene expression and impeding NF-κB activity-a transcription factor integral to IL-TIF expression. Another alkaloid, Stachydrine, exerts its inhibitory effects by targeting the NF-κB pathway, which is instrumental for IL-TIF's role in inflammation. By blocking this pathway, Stachydrine reduces the activation of genes regulated by IL-TIF, curtailing the protein's contribution to inflammation.
Moreover, a couple of kinase inhibitors, IMD-0354 and BMS-345541, impede enzymes that are critical for NF-κB activation, which is a precursor for IL-TIF production. IMD-0354 inhibits IKKβ, forestalling the nuclear translocation of NF-κB and, as a result, the transcription of IL-TIF. BMS-345541 operates similarly but targets both IKKα and IKKβ, disrupting the signaling pathway more broadly and hence IL-TIF expression. Caffeic acid phenethyl ester (CAPE) and parthenolide also inhibit NF-κB activation but through different molecular interactions. CAPE suppresses the transcription and production of IL-TIF by obstructing NF-κB activation, while parthenolide blocks the NF-κB pathway more upstream, preventing the transcriptional activity necessary for IL-TIF's production. Bay 11-7082 and JSH-23 target the NF-κB pathway as well, with Bay 11-7082 inhibiting the phosphorylation of IκBα and JSH-23 inhibiting the nuclear translocation of NF-κB, both leading to reduced IL-TIF production. Each chemical, through distinct molecular paths, ensures the functional inhibition of IL-TIF, highlighting the complexity and specificity of biochemical regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
IMD-0354 is an inhibitor of IKKβ, which is part of the IκB kinase complex that activates NF-κB. NF-κB is a key transcription factor for the production of IL-TIF. Inhibition of IKKβ by IMD-0354 prevents NF-κB from translocating to the nucleus and initiating transcription of IL-TIF, resulting in the functional inhibition of IL-TIF by reducing its production and activity in inflammation and immune response. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
BMS-345541 selectively inhibits IKKα and IKKβ, which are essential for activating NF-κB. By inhibiting these kinases, BMS-345541 disrupts the NF-κB signaling pathway, which is crucial for the expression and function of IL-TIF. The suppression of NF-κB activity leads to the functional inhibition of IL-TIF by reducing its expression and subsequent pro-inflammatory effects. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Caffeic acid phenethyl ester (CAPE) is an inhibitor of NF-κB activation. By inhibiting NF-κB, CAPE can suppress the transcription and production of IL-TIF, which is dependent on NF-κB for its expression. This results in the functional inhibition of IL-TIF by reducing its availability and its role in promoting inflammatory responses. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a sesquiterpene lactone that inhibits the NF-κB pathway. By blocking NF-κB, parthenolide inhibits the transcriptional activity necessary for IL-TIF production. This leads to the functional inhibition of IL-TIF by limiting its expression and the downstream inflammatory processes it induces. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 irreversibly inhibits the phosphorylation of IκBα, thereby inhibiting NF-κB activation. Since IL-TIF relies on NF-κB for its expression, the inhibition of NF-κB by Bay 11-7082 results in decreased IL-TIF production and activity, leading to functional inhibition. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
JSH-23 is an inhibitor of NF-κB nuclear translocation. By preventing NF-κB from entering the nucleus, JSH-23 reduces the transcription of NF-κB target genes, including the genes responsible for IL-TIF production. This inhibition diminishes IL-TIF's role in inflammatory responses, resulting in functional inhibition. | ||||||