IL-17REL Activators
IL-17REL is a member of the interleukin-17 (IL-17) family of cytokines, which are known for their role in inflammatory processes and host defense against infections. This family includes several members, such as IL-17A through IL-17F, each encoded by different genes and exhibiting distinct but related biological functions. IL-17 cytokines are predominantly produced by a unique subset of T cells known as Th17 cells, although other cell types like γδ T cells and innate immune cells can also produce them under certain conditions.
IL-17REL is the least characterized member of the IL-17 family and shares sequence homology with other IL-17 family cytokines, suggesting it may have similar biological activities. The "REL" suffix denotes its relationship to the other IL-17 family members, but also its distinctiveness, as it is not as extensively studied. Due to the naming conventions of cytokines, the "REL" might imply a relative or a homolog to the better-characterized IL-17 cytokines, particularly IL-17A and IL-17F, which are the most studied and are known to mediate pro-inflammatory responses.While the exact function of IL-17REL is not well-defined, it is presumed to be involved in immune system signaling pathways, contributing to the orchestration of immune responses. Like other IL-17 cytokines, it may play a role in inducing the production of other pro-inflammatory molecules, such as chemokines and cytokines, which recruit and activate other immune cells to the site of infection or inflammation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can lead to the activation of NF-κB, a transcription factor that can enhance the expression of IL-17REL. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS binds to TLR4, initiating a signaling cascade that activates NF-κB, potentially increasing IL-17REL expression in immune cells. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Resiquimod activates TLR7 and TLR8, leading to the induction of pro-inflammatory cytokines and could upregulate IL-17REL. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod, a TLR7 agonist, can stimulate the innate immune system and may induce the expression of IL-17REL. | ||||||
Dexamethasone Sodium Phosphate | 2392-39-4 | sc-204715 sc-204715A | 100 mg 500 mg | $55.00 $158.00 | 7 | |
These TLR9 agonists can promote the activation of NF-κB, leading to an increase in IL-17REL expression. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
This TLR1/2 agonist can trigger a signaling cascade resulting in NF-κB activation and potential IL-17REL upregulation. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
As a TLR3 agonist, it can activate IRF3 and NF-κB, possibly enhancing IL-17REL expression. | ||||||