IKK alpha Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is a selective inhibitor of IκB kinase (IKK), characterized by its ability to disrupt the phosphorylation cascade of IκB proteins. This compound exhibits unique binding affinity, altering the conformational state of IKK and impacting downstream signaling pathways. Its kinetic profile reveals a competitive inhibition mechanism, which effectively modulates the activation of NF-κB. The compound's structural features facilitate specific interactions that enhance its regulatory role in cellular processes. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
IKK-2 Inhibitor IV is a potent modulator of IκB kinase activity, distinguished by its selective interaction with the IKK complex. This compound engages in unique molecular interactions that stabilize the inactive form of IKK, thereby preventing substrate phosphorylation. Its kinetic behavior suggests a non-competitive inhibition mechanism, influencing the dynamics of NF-κB signaling. The inhibitor's structural characteristics promote specific binding, enhancing its role in cellular regulatory networks. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol acts as a selective inhibitor of IKK alpha, showcasing unique molecular interactions that disrupt the kinase's activation. By binding to specific sites, it alters the conformational dynamics of the IKK complex, effectively modulating downstream signaling pathways. Its reaction kinetics indicate a potential allosteric inhibition, which may influence the phosphorylation state of key substrates. This compound's structural features facilitate targeted engagement, impacting cellular processes significantly. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $108.00 $330.00 | 8 | |
Wedelolactone exhibits a distinctive mechanism as an IKK alpha modulator, characterized by its ability to selectively disrupt the kinase's activity through unique binding interactions. This compound engages with the IKK complex, inducing conformational changes that affect its functional dynamics. The kinetics of its interaction suggest a nuanced regulatory role, potentially influencing the phosphorylation of critical signaling molecules. Its structural attributes enable precise targeting, thereby impacting various cellular pathways. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
BMS-345541 functions as a selective inhibitor of IKK alpha, showcasing a unique binding affinity that alters the enzyme's conformation. This compound interacts with specific residues within the kinase domain, leading to a reduction in its catalytic activity. The reaction kinetics indicate a competitive inhibition mechanism, allowing for fine-tuning of downstream signaling pathways. Its structural characteristics facilitate targeted modulation, influencing cellular responses and regulatory networks. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $219.00 $924.00 | 2 | |
IKK 16 acts as a selective inhibitor of IKK alpha, exhibiting a distinct mechanism of action through its interaction with the enzyme's active site. This compound stabilizes a unique conformational state, disrupting the phosphorylation cascade essential for NF-kB activation. Its kinetic profile reveals a non-competitive inhibition pattern, which alters the dynamics of signal transduction. The compound's structural features enable precise modulation of cellular pathways, impacting various regulatory processes. | ||||||