IFT122 Inhibitors
IFT122 Inhibitors primarily operate by blocking the signaling pathways that IFT122 is directly involved in. This can be achieved by inhibiting protein kinases like PKC and JNK, as well as Src-family kinases, all of which are known to activate IFT122. Specific inhibitors for these kinases include Staurosporine, Dasatinib, SP600125, Go6983, and Ro-31-8220. By inhibiting these kinases, these chemical compounds can lead to a decrease in the activation of IFT122. Furthermore, the NF-κB pathway is known to activate IFT122, therefore, inhibitors like BAY 11-7082 and BAY 11-7085 that inhibits NF-κB activation can lead to decreased activation of IFT122.
Moreover, the MAPK pathway, specifically the MEK component, is known to activate IFT122. Therefore, MEK inhibitors like PD98059 and U0126 can decrease IFT122 activation. Additionally, the PI3K and mTOR signaling pathways are known to activate IFT122, soinhibitors such as LY294002 and Rapamycin, which block PI3K and mTOR respectively, can result in a decrease in IFT122 activation. The EGFR tyrosine kinase is another activator of IFT122, and its specific inhibitor, AG 1478, can also lead to decreased IFT122 activation. Through these specific biochemical pathways, the activity of IFT122 can be inhibited directly or indirectly by the listed chemical compounds.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC, a crucial mediator in several signaling pathways that IFT122 is involved in. By inhibiting PKC, Staurosporine can lead to a decrease in the activation of IFT122. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib inhibits Src-family kinases. These kinases are upstream activators of numerous proteins, including IFT122. Inhibition of Src-family kinases by Dasatinib could lead to decreased activation of IFT122. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK, a protein kinase that is part of the signaling cascade that activates IFT122. Inhibition of JNK by SP600125 can result in decreased activation of IFT122. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is a known activator of many proteins, including IFT122. Inhibition of PI3K by LY294002 can lead to decreased activation of IFT122. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 inhibits PKC, a known activator of IFT122. Inhibition of PKC by Go6983 can lead to decreased activation of IFT122. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking the cytokine-induced IκBα phosphorylation. Since NF-κB is a known activator of IFT122, inhibition of NF-κB by BAY 11-7082 can lead to decreased activation of IFT122. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor. MEK is part of the MAPK pathway, which is known to activate IFT122. Inhibition of MEK by PD98059 can lead to decreased activation of IFT122. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a PKC inhibitor. PKC is a known activator of IFT122. Inhibition of PKC by Ro-31-8220 can lead to decreased activation of IFT122. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
AG 1478 is a specific inhibitor of EGFR tyrosine kinase. EGFR is a known activator of many proteins, including IFT122. Inhibition of EGFR by AG 1478 can lead to decreased activation of IFT122. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $124.00 $526.00 | 55 | |
BAY 11-7085 inhibits NF-κB activation by blocking the cytokine-induced IκBα phosphorylation. Since NF-κB is a known activator of IFT122, inhibition of NF-κB by BAY 11-7085 can lead to decreased activation of IFT122. | ||||||