IFITM2 Activators
IFITM2 Activators are a class of chemical compounds associated with the modulation or enhancement of the biological activity of Interferon-Induced Transmembrane Protein 2 (IFITM2). IFITM2 is a member of the IFITM family of proteins, which are known for their role in host defense against various pathogens, particularly viruses. These proteins are widely expressed in various tissues and cellular compartments, including the endosomal and lysosomal membranes. IFITM2, like its homolog IFITM3, has garnered attention for its ability to restrict the entry and replication of a broad range of enveloped viruses, including influenza, SARS-CoV, and other coronaviruses.
IFITM2 Activators are believed to interact with IFITM2, influencing its membrane localization, conformation, or antiviral activity. The precise mechanisms by which these activators modulate IFITM2 function are areas of ongoing research, but it is understood that any alterations in IFITM2 activity can impact the ability of cells to resist viral infection. IFITM2, like IFITM3, acts as a potent barrier at the early stages of the viral life cycle by disrupting viral fusion and entry into host cells. By targeting IFITM2, these activators enhance or fine-tune the antiviral defenses of host cells against a range of infectious agents. Research in this area is vital for unraveling the molecular mechanisms underlying innate immune responses to viral infections and may provide insights into new strategies for combating viral diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
This synthetic analog of double-stranded RNA can mimic viral infection, triggering immune responses that may include the upregulation of IFITM2 as a protective measure against viral entry. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
This metabolite of Vitamin A is involved in immune function regulation and may influence the expression of IFITM2, possibly as part of a broader modulation of immune responses. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Known for its role in immune function, Cholecalciferol can influence various immune pathways, potentially including the upregulation of IFITM2 as a response to immune challenges. | ||||||
b-Glucan, Saccharomyces cerevisiae | 9012-72-0 | sc-203832 | 25 mg | $307.00 | ||
As a polysaccharide found in the cell walls of bacteria and fungi, beta-glucan can stimulate the immune system, potentially leading to the induction of IFITM2 in response to microbial exposure. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This plant compound, commonly found in grapes, can modulate various cellular pathways, potentially influencing the expression of IFITM2 as part of its immunomodulatory effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A bioactive compound in turmeric, curcumin can modulate multiple signaling pathways, potentially including those that lead to the upregulation of IFITM2 in response to immune challenges. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As an essential mineral, zinc plays a role in immune system function, potentially affecting the expression of IFITM2 through its involvement in various cellular processes. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
This essential micronutrient is crucial for immune function, and its presence may influence the expression of IFITM2 as part of the body's response to viral or bacterial challenges. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Found in many fruits and vegetables, quercetin can influence various cellular signaling pathways, potentially leading to the induction of IFITM2 as part of its immune-modulating effects. | ||||||