HYPE Inhibitors
HYPE inhibitors are chemical compounds that inhibit the activity of the HYPE protein, also known as FICD (Fic Domain-Containing Protein). HYPE is an enzyme that plays a pivotal role in the post-translational modification of proteins, a process critical for regulating various cellular functions. This enzyme is known for its unique activity of adding an adenylyl group ( found in ATP) to target proteins, a modification known as AMPylation. AMPylation, mediated by HYPE, can affect the function, interaction, and stability of various proteins within the cell.
The structure of HYPE includes a distinctive Fic domain, which is responsible for its enzymatic activity. This domain's active site is where the transfer of the adenylyl group to target proteins occurs, and it is also the key target site for the inhibitors. The precise mechanism of action of HYPE and its role in cellular processes have been subjects of extensive research, contributing to the interest in developing specific inhibitors for this enzyme.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It may alter chromatin structure and gene expression, potentially downregulating HYPE expression by changing the acetylation status of histones near the HYPE gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By inhibiting methylation, it can lead to the reactivation of silenced genes. It might decrease HYPE expression indirectly by affecting the expression of regulatory genes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. It affects protein synthesis and autophagy pathways, which could indirectly influence HYPE expression levels by altering cellular stress responses and protein turnover. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, known for its role in lysosomal inhibition, may affect cellular autophagy and degradation pathways. This could impact the turnover and degradation of HYPE, potentially reducing its overall expression levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, has been shown to modulate various molecular targets and pathways. Its potential effect on HYPE expression could be through the modulation of transcription factors and signaling pathways related to HYPE expression. | ||||||