HYPE Antibody (G-7): sc-515368
- HYPE Antibody (G-7) is a mouse monoclonal IgG1 κ HYPE antibody provided at 200 µg/ml
- raised against amino acids 159-458 mapping at the C-terminus of HYPE of human origin
- HYPE Antibody (G-7) is recommended for detection of HYPE of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-HYPE Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HYPE Antibody (G-7) for WB applications. These reagents are now offered in bundles with HYPE Antibody (G-7) (see ordering information below).
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HYPE Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects HYPE protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HYPE (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HYPE protein, also known as Huntingtin yeast partner E, is a 458 amino acid single-pass membrane protein that plays a critical role in cellular processes by interacting with the Huntingtin protein, which is implicated in neurodegenerative diseases when mutated. The presence of two tetratricopeptide repeats (TPR) in HYPE suggests involvement in protein-protein interactions, which are essential for various signaling pathways and cellular functions. Understanding HYPE interactions with other proteins can provide insights into neurodegeneration and other cellular mechanisms. The gene encoding HYPE is located on chromosome 12, a region associated with several skeletal deformities and crucial gene clusters that regulate morphogenesis and immune responses. The study of HYPE and associated interactions is vital for elucidating the underlying mechanisms of neurodegenerative diseases and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HYPE Antibody (G-7) References:
- The genomic context of natural killer receptor extended gene families. | Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
- The phenotypic spectrum of COL2A1 mutations. | Nishimura, G., et al. 2005. Hum Mutat. 26: 36-43. PMID: 15895462
- The natural history of trisomy 12p. | Segel, R., et al. 2006. Am J Med Genet A. 140: 695-703. PMID: 16502429
- Noonan syndrome. | van der Burgt, I. 2007. Orphanet J Rare Dis. 2: 4. PMID: 17222357
- Cytogenetic and molecular analysis in trisomy 12p. | Allen, TL., et al. 1996. Am J Med Genet. 63: 250-6. PMID: 8723118
- Huntingtin interacts with a family of WW domain proteins. | Faber, PW., et al. 1998. Hum Mol Genet. 7: 1463-74. PMID: 9700202
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HYPE Antibody (G-7) | sc-515368 | 200 µg/ml | $322.00 | |||
HYPE Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-528028 | 200 µg Ab; 10 µg BP | $361.00 | |||
HYPE Antibody (G-7): m-IgG1 BP-HRP Bundle | sc-533401 | 200 µg Ab; 20 µg BP | $361.00 | |||
HYPE Antibody (G-7) AC | sc-515368 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HYPE Antibody (G-7) HRP | sc-515368 HRP | 200 µg/ml | $322.00 | |||
HYPE Antibody (G-7) FITC | sc-515368 FITC | 200 µg/ml | $336.00 | |||
HYPE Antibody (G-7) PE | sc-515368 PE | 200 µg/ml | $349.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 488 | sc-515368 AF488 | 200 µg/ml | $364.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 546 | sc-515368 AF546 | 200 µg/ml | $364.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 594 | sc-515368 AF594 | 200 µg/ml | $364.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 647 | sc-515368 AF647 | 200 µg/ml | $364.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 680 | sc-515368 AF680 | 200 µg/ml | $364.00 | |||
HYPE Antibody (G-7) Alexa Fluor® 790 | sc-515368 AF790 | 200 µg/ml | $364.00 |