HURP Activators
The class of chemicals known as HURP Activators encompasses a diverse range of compounds that influence various cellular pathways and processes, potentially leading to the activation of HURP. These chemicals do not activate HURP directly but instead modulate cellular signaling and metabolic pathways, creating an environment that can facilitate HURP's functional role in cell division, particularly in mitotic spindle assembly and chromosome alignment.
The mechanisms through which these chemicals act are varied and complex. For instance, compounds like Forskolin and Rapamycin alter intracellular signaling pathways like cAMP and mTOR, respectively, influencing the cell's regulatory environment. This can lead to changes in microtubule dynamics or cellular stress responses, indirectly affecting HURP's activity. Other chemicals, such as Lithium chloride and U0126, target specific enzymes like GSK-3β and MEK1/2, altering well-established signaling cascades like Wnt and ERK/MAPK pathways. These alterations can indirectly impact HURP, given its role in spindle assembly and cell division. Additionally, compounds like Nocodazole and Y-27632 affect the physical components of the cell, such as microtubules and the cytoskeleton, which are crucial for HURP's function during mitosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP can modulate various signaling pathways, potentially influencing microtubule dynamics and indirectly affecting HURP's role in spindle assembly. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which plays a role in various cellular processes, including cell cycle regulation. PKC activation can indirectly influence HURP by modulating the cellular environment during mitosis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase involved in Wnt signaling. While avoiding direct Wnt pathway activators, inhibition of GSK-3β can alter cellular processes that may indirectly affect HURP's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. By influencing these cellular processes, rapamycin can indirectly impact HURP activity during cell division. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, impacting cellular stress response pathways. This modulation can indirectly influence HURP by altering the cellular environment during mitosis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, affecting the AKT signaling pathway. This can lead to changes in cell survival and proliferation signals, indirectly impacting HURP activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It broadly influences signaling pathways, potentially affecting cellular processes that indirectly modulate HURP function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which affects the ERK/MAPK pathway. This can lead to altered cell cycle progression, potentially impacting HURP's role in mitosis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, affecting cellular energy metabolism. This metabolic stress can influence cell cycle events, potentially impacting HURP's function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, affecting spindle assembly. This disruption can indirectly influence HURP's role in maintaining spindle integrity. | ||||||