HSPBAP1 Activators
HSPBAP1 Activators are a diverse group of chemicals that interact with various cellular pathways, ultimately leading to the enhancement of the functional activity of HSPBAP1. For instance, Resveratrol, Quercetin, and EGCG are plant-derived polyphenols that activate HSF1 or inhibit the PI3K/Akt/mTOR pathway, therefore increasing HSPBAP1 activity. Lithium, an element used as a mood stabilizer, acts by inhibiting GSK-3β, and this inhibition leads to mTOR pathway activation and subsequent upregulation of HSPBAP1.
The remaining compounds are primarily HSP90 inhibitors (17-DMAG) or AMPK activators (Metformin, AICAR, NZ28). HSP90 inhibitors trigger the heat shock response, a cellular stress response leading to upregulation of HSPs, including HSPBAP1. KNK437, although it inhibits HSP synthesis, can also lead to upregulation of HSPBAP1 as a compensatory response. AMPK activators like Metformin, AICAR, and NZ28 induce HSP expression, thereby enhancing HSPBAP1 activity. These diverse compounds, acting through their distinct pathways, all lead to the functional activation of HSPBAP1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that activates sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase. SIRT1 deacetylates heat shock factor 1 (HSF1), a transcription factor that upregulates the expression of heat shock proteins (HSPs), including HSPBAP1. Increased HSPBAP1 function is expected upon resveratrol stimulation of SIRT1 and subsequent HSF1 activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the primary catechin found in green tea. It's known to inhibit the PI3K/Akt/mTOR pathway, which plays a role in regulating heat shock protein (HSP) expression. By inhibiting this pathway, EGCG may indirectly enhance the expression and function of HSPBAP1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, has been shown to activate HSF1, which subsequently induces the expression of HSPBAP1. This process leads to an increased functional activity of HSPBAP1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is a mood-stabilizing agent and it inhibits GSK-3β. The inhibition of GSK-3β leads to the activation of the mTOR pathway which is known to upregulate the production of HSPs including HSPBAP1. | ||||||
17-DMAG | 467214-20-6 | sc-202005 | 1 mg | $205.00 | 8 | |
17-DMAG is a derivative of Geldanamycin and acts as an HSP90 inhibitor. Similar to other HSP90 inhibitors, it triggers the heat shock response, leading to upregulation of HSPBAP1. | ||||||
Heat Shock Protein Inhibitor I | 218924-25-5 | sc-221709 | 5 mg | $97.00 | 5 | |
KNK437 is a benzylidene lactam compound, and it inhibits the synthesis of heat shock proteins (HSPs). However, the inhibition of the synthesis of other HSPs can lead to the upregulation of HSPBAP1 as a compensatory response. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMPK, leading to the upregulation of HSPs. This process can enhance the functional activity of HSPBAP1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. Its activation of AMPK can lead to an increased expression and functional activity of HSPBAP1. | ||||||