HoxC8 Activators
The chemistry of HoxC8 activators is diverse, spanning retinoids, corticoids, phytoestrogens, and kinase inhibitors, among others. These compounds exert influence on HoxC8 by modulating various cellular processes and signaling pathways. Retinoic Acid and Forskolin, for instance, act by binding to specific receptors and activating downstream signaling, respectively, thus modifying the transcriptional activity of HoxC8. 5-Azacytidine and Sodium Butyrate, on the other hand, operate on an epigenetic level, altering the methylation and acetylation status of the HoxC8 gene to regulate its expression.
Dexamethasone and Genistein are examples of hormone-like compounds that can indirectly influence HoxC8 expression through hormone receptor signaling. Lithium Chloride and Verapamil, on the other hand, modify intracellular signaling pathways by inhibiting specific enzymes or cellular functions. Finally, compounds like Staurosporine display broad activity across multiple targets, providing an indirect means of influencing HoxC8 activity. The heterogeneity of these compounds and their mechanisms of action reflects the complex interplay of cellular processes regulating the function of transcription factors like HoxC8.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a metabolite of Vitamin A, can influence the expression of Hox genes including HoxC8 by binding to retinoic acid receptors (RARs). This leads to the activation of RARs and subsequent alteration of the transcriptional activity of HoxC8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a diterpene, activates adenylate cyclase, leading to increased cAMP levels. This can indirectly influence HoxC8 by modulating PKA activity and subsequent phosphorylation events, which can alter transcription factor functions. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It can increase the expression of HoxC8 by reducing methylation, a form of epigenetic silencing, thereby facilitating the transcription of HoxC8. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, a primary female sex hormone, can modulate the expression of Hox genes indirectly through the activation of estrogen receptor signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can influence HoxC8 expression indirectly by activating glucocorticoid receptor signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK3-beta, a kinase involved in numerous cellular pathways. Its inhibition can indirectly influence HoxC8 through modifying pathways that regulate transcription factor activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase (HDAC) inhibitor. It can upregulate HoxC8 expression by increasing histone acetylation, another form of epigenetic modification that promotes gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate (EGCG) has been shown to influence DNA methylation. This can potentially affect HoxC8 expression by altering the methylation status of its promoter region. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. It can indirectly affect HoxC8 by modulating mTOR signaling, which plays a significant role in cell growth and proliferation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Its broad range of targets can indirectly influence the activity of numerous transcription factors including HoxC8. | ||||||