HoxA13 Activators
HoxA13, a critical transcription factor in embryonic development, is modulated by a diverse array of chemical compounds that intricately influence its activity. Retinoic Acid (302-79-4) and Estradiol (50-28-2) are paramount in this regulation, with Retinoic Acid binding to RARs to modulate HoxA13 transcription in developmental pathways, and Estradiol enhancing HoxA13 expression via estrogen receptors, especially in female reproductive tissues. Dihydrotestosterone (521-18-6) also plays a significant role, particularly in male genital development, by augmenting HoxA13 expression through androgen receptor interaction. Nutrient-related compounds such as Folic Acid (59-30-3) contribute by ensuring proper methylation and DNA synthesis, pivotal for HoxA13 function in embryogenesis, while Vitamin D3 (67-97-0) enhances HoxA13 expression in vitamin D responsive tissues through its receptor-mediated action.
The functionality of HoxA13 is further influenced by compounds that modify chromatin and DNA states. Sodium Butyrate (156-54-7) and Trichostatin A (58880-19-6), as histone deacetylase inhibitors, facilitate transcriptionally active chromatin states near the HOXA13 gene, promoting its expression. 5-Azacytidine (320-67-2), by inhibiting DNA methylation, can activate silenced genes, potentially enhancing HoxA13 expression. Additionally, Lithium Chloride (7447-41-8), through its influence on the Wnt signaling pathway, and Forskolin (66575-29-9), via elevating cAMP levels, contribute to the regulation of HoxA13 through signaling pathways that intersect with Hox gene regulation. Epigallocatechin Gallate (989-51-5) and Bisphenol A (80-05-7) also play roles in modulating HoxA13 activity, the former through its effects on oxidative stress-related pathways, and the latter by mimicking estrogenic activity, influencing Hox gene expression in estrogen-sensitive tissues. Collectively, these compounds enhance the functional activity of HoxA13, pivotal for its roles in development and organogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Enhances HoxA13 functional activity by binding to retinoic acid receptors (RARs) which regulate Hox genes, leading to activation of these receptors and modulation of HoxA13 transcription in limb development and organogenesis. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Binds to estrogen receptors, enhancing HoxA13 expression, particularly in female reproductive tissues, influencing developmental processes. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Essential for methylation processes and DNA synthesis, influencing epigenetic modifications that regulate HoxA13 gene expression, critical for proper HoxA13 function during embryonic development. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Acts as a histone deacetylase inhibitor, modifying chromatin structure and affecting HoxA13 gene expression by altering the chromatin state in regions proximal to HOXA13, facilitating transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor, influences HoxA13 expression by altering chromatin accessibility and promoting a transcriptionally active chromatin state, potentially increasing HoxA13 gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that enhances HoxA13 expression by demethylating the promoter region of the HOXA13 gene, facilitating transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Activates the Wnt signaling pathway, indirectly enhancing HoxA13 expression, contributing to its role in developmental processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels and PKA activity, influencing HoxA13 gene expression by modulating transcription factors that bind to the HOXA13 promoter region. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Through its active form, calcitriol, binds to the Vitamin D receptor, influencing HoxA13 expression in vitamin D responsive tissues. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Affects various signaling pathways, including those regulating gene expression, and may indirectly enhance HoxA13 activity by modulating pathways intersecting with Hox gene regulation, such as oxidative stress-related pathways. | ||||||