Date published: 2025-12-5

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 21 to 30 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1,1-Methanediyl Bismethanethiosulfonate

22418-52-6sc-208706
10 mg
$301.00
1
(0)

1,1-Methanediyl Bismethanethiosulfonate is a homobifunctional reagent known for its dual thiol-reactive groups, enabling the formation of disulfide bonds through thiol exchange reactions. This compound exhibits remarkable selectivity in cross-linking, allowing for the precise manipulation of molecular structures. Its unique reactivity facilitates the creation of complex networks, influencing reaction kinetics and enhancing the stability of resultant conjugates in various chemical environments.

1,5-Diazido-3-oxapentane

24345-74-2sc-208800
1 g
$320.00
(0)

1,5-Diazido-3-oxapentane is a homobifunctional compound characterized by its dual azide groups, which engage in efficient click chemistry reactions. This compound exhibits a high degree of reactivity, enabling rapid cycloaddition with alkenes and alkynes, leading to stable triazole linkages. Its unique structure promotes selective functionalization, allowing for the precise assembly of complex molecular architectures while influencing the kinetics of reaction pathways in diverse chemical contexts.

1,4-Bis-maleimidobutane

28537-70-4sc-208788
10 mg
$265.00
(0)

1,4-Bis-maleimidobutane is a homobifunctional compound featuring two maleimide groups that facilitate thiol-ene click reactions. This compound exhibits a strong propensity for forming covalent bonds with thiol-containing molecules, resulting in stable thioether linkages. Its symmetrical structure enhances the efficiency of cross-linking, promoting the formation of robust networks. The reactivity of the maleimide moieties allows for controlled polymerization and tailored material properties in various chemical environments.

Dimethyl 3,3′-dithiopropionimidate dihydrochloride

38285-78-8sc-252733
100 mg
$86.00
(0)

Dimethyl 3,3'-dithiopropionimidate dihydrochloride is a homobifunctional reagent characterized by its dual dithiopropionimidate groups, which enable selective interactions with nucleophiles. This compound exhibits unique reactivity through its ability to form disulfide bonds, facilitating the creation of cross-linked networks. Its distinct pathway for thiol modification allows for precise control over reaction kinetics, making it suitable for applications requiring specific molecular architectures and enhanced stability.

Disuccinimidyl L-Tartrate

62069-75-4sc-211361
250 mg
$214.00
(0)

Disuccinimidyl L-Tartrate is a homobifunctional crosslinker featuring two reactive succinimidyl groups that enable efficient conjugation with amine-containing molecules. Its unique reactivity profile allows for rapid formation of stable amide bonds, facilitating the creation of complex molecular architectures. The compound's ability to engage in selective coupling reactions enhances its utility in constructing intricate biomolecular networks, while its steric properties influence the spatial arrangement of linked entities.

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)

70539-42-3sc-252807
sc-252807A
250 mg
1 g
$126.00
$398.00
2
(0)

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional crosslinker characterized by its dual reactive sites that promote efficient coupling with nucleophiles. Its distinct reactivity allows for the formation of stable linkages through amide bond formation, enabling the construction of diverse polymeric structures. The compound's hydrophilic nature enhances solubility in aqueous environments, while its flexible backbone facilitates conformational adaptability, influencing the dynamics of assembled networks.

Bis(sulphosuccinimidyl)suberate

87067-99-0sc-353092
100 mg
$240.00
(0)

Bis(sulphosuccinimidyl)suberate is a homobifunctional crosslinker featuring two reactive succinimidyl groups that enable robust covalent bonding with amine-containing molecules. Its unique structure promotes the formation of stable amide linkages, facilitating the creation of complex molecular architectures. The compound exhibits a high degree of specificity in its interactions, allowing for precise control over reaction kinetics and enhancing the stability of assembled structures in various environments.

1,11-Diazido-3,6,9-trioxaundecane

101187-39-7sc-208716
1 g
$515.00
(0)

1,11-Diazido-3,6,9-trioxaundecane is a homobifunctional compound characterized by its dual azide groups, which enable selective and efficient click chemistry reactions. This unique feature allows for rapid and specific conjugation with alkyne-containing partners, facilitating the formation of diverse polymeric networks. Its trioxaundecane backbone contributes to enhanced solubility and flexibility, promoting effective molecular interactions and enabling tailored assembly in various chemical environments.

1,8-Bis-maleimidotetraethyleneglycol

115597-84-7sc-208810
25 mg
$245.00
(0)

1,8-Bis-maleimidotetraethyleneglycol is a homobifunctional compound distinguished by its two maleimide groups, which engage in thiol-ene click reactions, promoting robust covalent bonding with thiol-containing molecules. This dual reactivity enhances the formation of cross-linked networks, providing structural integrity and stability. The tetraethylene glycol spacer imparts hydrophilicity and flexibility, facilitating dynamic interactions in aqueous environments and optimizing reaction kinetics for diverse applications.

DPDPB

141647-62-3sc-237746
10 mg
$131.00
(0)

DPDPB is a homobifunctional compound characterized by its two reactive acid halide groups, which readily undergo acylation reactions with nucleophiles, such as amines and alcohols. This dual functionality allows for the efficient formation of diverse linkages, promoting the synthesis of complex molecular architectures. Its unique reactivity profile enables selective modifications, enhancing the versatility of reaction pathways and facilitating the development of tailored materials with specific properties.