Dimethyl 3,3'-dithiopropionimidate dihydrochloride is a thiol-cleavable, homobifunctional amine-reactive crosslinker. It has been shown to react with primary amines in the pH range 7.0-10.0 to form amidine bonds.
Note that the amidine linkage preserves original primary amine (+)charge. It incorporates an 8 atom spacer arm.
Ruoho, A., et al., A disulfide-bridge bifunctional imidoester as a reversible cross-linking reagent. Biochem. Biophys. Res. Commun. 63, 417-423, (1975)
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