Date published: 2025-10-21

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1,4-Bis-maleimidobutane (CAS 28537-70-4)

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Application:
1,4-Bis-maleimidobutane is a thiol reactive crosslinking reagent
CAS Number:
28537-70-4
Molecular Weight:
248.23
Molecular Formula:
C12H12N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Bis-maleimidobutane is a short, sulfhydryl reactive homobifunctional crosslinking reagent. This reagent is highly valuable in biochemical and physiological experiments due to its ability to create covalent bonds with diverse molecules. In scientific research, 1,4-Bis-maleimidobutane finds various applications.


1,4-Bis-maleimidobutane (CAS 28537-70-4) References

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  6. PAB1 self-association precludes its binding to poly(A), thereby accelerating CCR4 deadenylation in vivo.  |  Yao, G., et al. 2007. Mol Cell Biol. 27: 6243-53. PMID: 17620415
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  8. A synergistic small-molecule combination directly eradicates diverse prion strain structures.  |  Roberts, BE., et al. 2009. Nat Chem Biol. 5: 936-46. PMID: 19915541
  9. Countering amyloid polymorphism and drug resistance with minimal drug cocktails.  |  Duennwald, ML. and Shorter, J. 2010. Prion. 4: 244-51. PMID: 20935457
  10. Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans.  |  Duennwald, ML., et al. 2012. PLoS Biol. 10: e1001346. PMID: 22723742
  11. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.  |  Desantis, ME., et al. 2014. J Biol Chem. 289: 848-67. PMID: 24280225
  12. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation.  |  Sweeny, EA., et al. 2015. Mol Cell. 57: 836-849. PMID: 25620563

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Bis-maleimidobutane, 10 mg

sc-208788
10 mg
$265.00