Date published: 2026-3-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) (CAS 70539-42-3)

0.0(0)
Write a reviewAsk a question

See product citations (2)

Alternate Names:
EGS
Application:
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable, amine-reactive crosslinker, 12 atom spacer arm
CAS Number:
70539-42-3
Molecular Weight:
456.36
Molecular Formula:
C18H20N2O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable, amine-reactive crosslinker. It is usually coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) and contains a 12-atom spacer arm.Used in ChIP assays to determine DNA-protein binding interactions.


Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) (CAS 70539-42-3) References

  1. Generation of cell-free extracts of Xenopus eggs and demembranated sperm chromatin for the assembly and isolation of in vitro-formed nuclei for Western blotting and scanning electron microscopy (SEM).  |  Allen, TD., et al. 2007. Nat Protoc. 2: 1173-9. PMID: 17546012
  2. Characterization of enhanced monovalent and bivalent thrombin DNA aptamer binding using single molecule force spectroscopy.  |  Neundlinger, I., et al. 2011. Biophys J. 101: 1781-7. PMID: 21961605
  3. The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length.  |  Helassa, N., et al. 2012. FEBS J. 279: 2071-81. PMID: 22487093
  4. The monoclonal antibody 22/18 recognizes a conformational change in an intermediate filament of the newt, Notophthalmus viridescens, during limb regeneration.  |  Ferretti, P. and Brockes, JP. 1990. Cell Tissue Res. 259: 483-93. PMID: 2317841
  5. Polyaspartamide-doxorubicin conjugate as potential prodrug for anticancer therapy.  |  Di Meo, C., et al. 2015. Pharm Res. 32: 1557-69. PMID: 25366547
  6. Fabrication of homobifunctional crosslinker stabilized collagen for biomedical application.  |  Lakra, R., et al. 2015. Biomed Mater. 10: 065015. PMID: 26610606
  7. Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members.  |  Otto, M., et al. 2016. Plants (Basel). 5: PMID: 27135223
  8. Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Synthesis, characterization and evaluation for targeted drug delivery.  |  Bhattacherjee, A., et al. 2016. Int J Pharm. 509: 507-517. PMID: 27234699
  9. Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Application for targeted drug delivery in experimental diabetes (Part 2).  |  Bhattacherjee, A. and Chakraborti, AS. 2017. Int J Pharm. 528: 8-17. PMID: 28559218
  10. Collagen Stiffness and Architecture Regulate Fibrotic Gene Expression in Engineered Adipose Tissue.  |  Di Caprio, N. and Bellas, E. 2020. Adv Biosyst. 4: e1900286. PMID: 32529801
  11. Optimized in vitro three-dimensional invasion assay for quantifying a wide range of cancer cell invasive behavior.  |  Hill, SM., et al. 2022. STAR Protoc. 3: 101516. PMID: 35780429
  12. Preparation of pure oligonucleotide-alkaline phosphatase conjugates.  |  Reyes, RA. and Cockerell, GL. 1993. Nucleic Acids Res. 21: 5532-3. PMID: 8265376
  13. The 18-kilodalton Chlamydia trachomatis histone H1-like protein (Hc1) contains a potential N-terminal dimerization site and a C-terminal nucleic acid-binding domain.  |  Pedersen, LB., et al. 1996. J Bacteriol. 178: 994-1002. PMID: 8576073

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester), 250 mg

sc-252807
250 mg
$129.00

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester), 1 g

sc-252807A
1 g
$406.00