HMBOX1 Activators are a class of chemical compounds that have garnered significant attention in the field of molecular biology and cellular research due to their ability to modulate the activity of the HMBOX1 protein. HMBOX1, short for Homeobox-Containing Protein 1, is a transcription factor that plays a crucial role in regulating gene expression and, consequently, various cellular processes. Activators of HMBOX1 are chemical compounds that enhance the transcriptional activity or expression of the HMBOX1 gene. These compounds are characterized by their ability to bind to specific molecular targets within the cell, ultimately leading to an upregulation of HMBOX1 expression and, subsequently, the downstream genes under its control.
The mechanism of action of HMBOX1 Activators involves their interaction with key regulatory elements, such as enhancers or promoters, that are associated with the HMBOX1 gene. This interaction can lead to increased binding of transcription factors or other co-regulators, facilitating the recruitment of RNA polymerase and other transcriptional machinery to the HMBOX1 gene. As a result, there is an enhanced production of HMBOX1 protein, which, in turn, can impact the expression of genes involved in processes like cell proliferation, differentiation, and development. Researchers are exploring the implications of HMBOX1 Activators in understanding fundamental biological processes and gene regulation, shedding light on their role in cellular homeostasis and function. These compounds are valuable tools for dissecting the intricate mechanisms of gene regulation, providing insights into the complex interplay of transcription factors and their downstream targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hematin | 15489-90-4 | sc-207729 sc-207729A sc-207729D sc-207729C | 250 mg 1 g 100 g 10 g | $73.00 $80.00 $5728.00 $734.00 | 1 | |
Hematin are synthetic and naturally occurring forms of heme. They activate HMBOX1 by providing heme as a substrate for the enzyme's activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
ZnPP is a metalloporphyrin that indirectly activates HMBOX1 by competing with heme, preventing its inhibitory effect on the enzyme. | ||||||
Tin Protoporphyrin IX dichloride | 14325-05-4 | sc-203452 sc-203452A sc-203452B | 5 mg 25 mg 1 g | $77.00 $263.00 $973.00 | 70 | |
SnPP is a metalloporphyrin similar to CoPP. It activates HMBOX1 by mimicking heme's structure and promoting the enzyme's activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol found in turmeric. It activates HMBOX1 through various mechanisms, including upregulating its expression and promoting its enzymatic activity. Curcumin also has antioxidant and anti-inflammatory properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound found in red grapes. It activates HMBOX1 by increasing its expression and promoting its enzymatic activity, contributing to its antioxidant effects. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in plants. It activates HMBOX1 by upregulating the enzyme's expression and enhancing its activity, contributing to its antioxidant and anti-inflammatory properties. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is a derivative of cysteine. It indirectly activates HMBOX1 by increasing intracellular glutathione levels, which promote the activity of HMBOX1, as the enzyme requires glutathione as a cofactor. | ||||||