HIV GAG Activators
HIV GAG activators are a class of compounds that enhance the expression or activity of the HIV GAG protein. GAG is a crucial structural protein of HIV-1, the virus that causes AIDS. GAG plays a critical role in the assembly and release of new viral particles.
HIV GAG activators exert their effect by modulating different aspects of GAG biology. Some HIV GAG activators, such as tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and interferon gamma (IFN-γ), are pro-inflammatory cytokines that activate specific signaling pathways leading to increased GAG expression. Other HIV GAG activators, such as lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), ionomycin, and thapsigargin, activate different signaling pathways that converge on the activation of the calcineurin signaling pathway, which leads to increased GAG expression. By modulating GAG expression or activity, HIV GAG activators can influence various aspects of the HIV-1 life cycle and pathogenesis. These compounds have been instrumental in dissecting the molecular mechanisms underlying GAG function and its involvement in HIV-1 replication, assembly, and release.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
A component of the outer membrane of Gram-negative bacteria that activates the TLR4 signaling pathway, leading to increased HIV GAG expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A protein kinase C activator that activates the NF-κB signaling pathway, leading to increased HIV GAG expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, leading to the activation of the calcineurin signaling pathway and increased HIV GAG expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A sarcoplasmic reticulum Ca2+-ATPase inhibitor that increases intracellular calcium levels, leading to the activation of the calcineurin signaling pathway and increased HIV GAG expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
A calcineurin inhibitor that blocks the activation of the calcineurin signaling pathway and reduces HIV GAG expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that blocks the activation of the mTOR signaling pathway and reduces HIV GAG expression. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
An mTOR inhibitor that blocks the activation of the mTOR signaling pathway and reduces HIV GAG expression. | ||||||