Histone cluster 3 H3 Inhibitors
Histone cluster 3 H3 inhibitors represent a specialized chemical class designed to selectively target and modulate the function of H3 histone proteins. Within the vast landscape of histone variants, H3 plays a pivotal role in the regulation of chromatin architecture and gene expression. As an essential component of nucleosomes, H3 contributes significantly to the compaction of DNA, influencing the dynamics of gene regulation within the cellular context. The inhibitors developed for Histone cluster 3 H3 are intricately designed to interact with the specific molecular structure of this histone variant, with the goal of perturbing its normal interactions within the nucleosome and potentially influencing the broader chromatin landscape.
The molecular architecture of Histone cluster 3 H3 inhibitors is precisely tailored to engage with specific binding sites on H3, inducing changes in its conformation and dynamics. This interaction holds the potential to impact the accessibility of DNA, thereby influencing the regulatory processes governing gene expression. In laboratory settings, researchers employ these inhibitors as powerful tools to dissect the nuanced roles of H3 in various cellular processes, contributing to an enhanced understanding of chromatin biology. By manipulating the function of H3, scientists seek to unravel the intricate mechanisms of gene regulation, shedding light on the broader implications of epigenetic processes for cellular function and development. The study of Histone cluster 3 H3 inhibitors stands at the forefront of advancing our comprehension of chromatin dynamics and the finely tuned orchestration of gene expression within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor, impacting DNA methylation patterns. Altered methylation may influence the transcriptional regulation of H3 clustered histone 14. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294 is a histone methyltransferase inhibitor targeting G9a, affecting histone methylation patterns. Modulation of these patterns may play a role in inhibiting H3 clustered histone 14 expression. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $112.00 | ||
Tubastatin A is a histone deacetylase 6 (HDAC6) inhibitor, influencing histone acetylation. Alterations in acetylation levels may impact the transcriptional regulation of H3 clustered histone 14. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is a histone methyltransferase G9a inhibitor, affecting histone methylation patterns. Modulation of these patterns may play a role in inhibiting H3 clustered histone 14 expression. | ||||||
GSK J1 | 1373422-53-7 | sc-391113 sc-391113A | 10 mg 50 mg | $189.00 $797.00 | ||
GSK-J1 is a histone demethylase inhibitor, influencing histone methylation patterns. Altered methylation may impact the transcriptional regulation of H3 clustered histone 14. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
CI-994 is a histone deacetylase inhibitor, promoting histone hyperacetylation. This epigenetic modification could potentially interfere with the expression of H3 clustered histone 14. | ||||||
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
OTX015 is a bromodomain and extraterminal (BET) protein inhibitor, disrupting the binding of BET proteins to acetylated histones. This interference may impact the transcription of H3 clustered histone 14. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a DOT1L inhibitor, targeting histone H3 lysine 79 methylation. Disruption of this methylation pattern may impact the transcriptional regulation of H3 clustered histone 14. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
CPTH2 is a histone acetyltransferase inhibitor, affecting histone acetylation. Modulation of acetylation levels may play a role in inhibiting the expression of H3 clustered histone 14. | ||||||
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
SGC-CBP30 is a histone acetyltransferase p300/CBP inhibitor, affecting histone acetylation. Modulation of acetylation levels may play a role in inhibiting the expression of H3 clustered histone 14. | ||||||