hippocalcin Inhibitors
The chemical class termed hippocalcin inhibitors encompasses a range of compounds meticulously selected to modulate the expression and function of hippocalcin. Among these, KN-62 emerges as a notable inhibitor directly targeting CaMKII, which influences the Ca2+/calmodulin signaling pathway. The downstream effect of this inhibition is the indirect modulation of hippocalcin, a Ca2+-sensitive protein intricately linked to this pathway. KN-62's specificity for CaMKII ensures precise control over the Ca2+/calmodulin pathway, subsequently impacting hippocalcin expression and function. Calmidazolium, another member of this chemical class, inhibits calmodulin, affecting the Ca2+/calmodulin pathway. This disruption leads to indirect modulation of hippocalcin, a downstream effector of calmodulin. Calmidazolium's selectivity for calmodulin ensures specific control over the Ca2+/calmodulin pathway, influencing hippocalcin expression and function. In addition to direct inhibitors, compounds like W-13, ML-7, and A-484954 exert their effects by influencing the Ca2+/calmodulin pathway through specific targets like calmodulin and myosin light chain kinase, subsequently modulating hippocalcin.
Other compounds, such as CGP 37157 and Ruthenium Red, focus on modulating Ca2+ homeostasis through inhibition of mitochondrial Na+/Ca2+ exchanger and non-selective inhibition of transient receptor potential (TRP) channels, respectively. These compounds indirectly impact hippocalcin, as hippocalcin is responsive to changes in cellular Ca2+ dynamics. The specificity or non-selectivity of these compounds ensures a broad or targeted influence on Ca2+ dynamics, subsequently modulating hippocalcin expression and function. In conclusion, the hippocalcin inhibitors chemical class provides a toolkit for precise modulation of hippocalcin expression and function through targeted interference with the Ca2+/calmodulin pathway and Ca2+ homeostasis. Each compound within this class exerts its influence through specific biochemical or cellular pathways, showcasing the intricacies of cellular signaling networks and providing valuable tools for the scientific exploration of hippocalcin function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 is a CaMKII inhibitor that directly targets CaMKII, influencing the Ca2+/calmodulin signaling pathway. By disrupting this pathway, KN-62 indirectly modulates hippocalcin, as hippocalcin is a downstream effector of Ca2+/calmodulin. KN-62's selectivity for CaMKII ensures specific control over the pathway and subsequent modulation of hippocalcin. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Calmidazolium inhibits calmodulin, affecting the Ca2+/calmodulin pathway. This inhibition leads to indirect modulation of hippocalcin, a downstream target of calmodulin. Calmidazolium's selectivity for calmodulin ensures specific control over the Ca2+/calmodulin pathway, influencing hippocalcin expression and function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is a myosin light chain kinase (MLCK) inhibitor impacting the Ca2+/calmodulin pathway. By targeting MLCK, ML-7 indirectly modulates hippocalcin, a downstream target of this pathway. ML-7's specificity for MLCK ensures precise control over the Ca2+/calmodulin pathway, influencing hippocalcin expression and function. | ||||||
A 484954 | 142557-61-7 | sc-479613 | 10 mg | $175.00 | ||
A-484954 is a TRPC3 channel blocker, influencing the Ca2+/calmodulin pathway. This inhibition leads to indirect modulation of hippocalcin, as hippocalcin is intricately linked to Ca2+/calmodulin signaling. A-484954's specificity for TRPC3 ensures selective control over the pathway, subsequently modulating hippocalcin expression and function. | ||||||
Compound 48/80 trihydrochloride | 94724-12-6 | sc-200736 sc-200736A sc-200736B sc-200736C | 100 mg 250 mg 1 g 5 g | $102.00 $214.00 $826.00 $3682.00 | ||
Compound 48/80 is a mast cell degranulator that indirectly influences hippocalcin through the Ca2+/calmodulin pathway. By promoting Ca2+ release, Compound 48/80 modulates the activity of hippocalcin, a downstream effector of this pathway. The compound's selectivity for mast cells ensures specific control over the Ca2+/calmodulin pathway, impacting hippocalcin expression. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $113.00 $454.00 | 3 | |
CGP 37157 is an inhibitor of the mitochondrial Na+/Ca2+ exchanger, influencing the Ca2+ homeostasis. By affecting Ca2+ levels, CGP 37157 indirectly modulates hippocalcin, as hippocalcin is sensitive to cellular Ca2+ changes. CGP 37157's specificity for the mitochondrial Na+/Ca2+ exchanger ensures selective control over Ca2+ homeostasis, subsequently impacting hippocalcin expression. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is a non-selective inhibitor of transient receptor potential (TRP) channels, affecting Ca2+ entry. By modulating Ca2+ levels, Ruthenium Red indirectly influences hippocalcin, as hippocalcin is responsive to changes in cellular Ca2+. The compound's non-selectivity for TRP channels ensures a broad impact on Ca2+ homeostasis, subsequently modulating hippocalcin expression. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF 96365 is a non-selective inhibitor of store-operated calcium entry (SOCE), impacting Ca2+ homeostasis. Through inhibition of SOCE, SKF 96365 indirectly modulates hippocalcin, a Ca2+-sensitive protein. The compound's non-selectivity for SOCE ensures a broad influence on Ca2+ dynamics, subsequently modulating hippocalcin expression and function. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $87.00 | ||
Gadolinium is a non-selective inhibitor of stretch-activated channels, affecting Ca2+ influx. By modulating Ca2+ entry, Gadolinium indirectly influences hippocalcin, a Ca2+-sensitive protein. The compound's non-selectivity for stretch-activated channels ensures a broad impact on Ca2+ dynamics, subsequently modulating hippocalcin expression and function. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
NNC 55-0396 is a selective inhibitor of phospholipase C (PLC), impacting the IP3-mediated Ca2+ release. By targeting PLC, NNC 55-0396 indirectly modulates hippocalcin, a downstream effector of IP3-mediated Ca2+ release. The compound's selectivity for PLC ensures precise control over the IP3-mediated pathway, subsequently modulating hippocalcin expression and function. | ||||||