HIP1 Inhibitors
HIP1 (Huntingtin Interacting Protein 1) inhibitors refer to a group of chemical compounds that are known to interact with and modulate the activity of the HIP1 protein. HIP1 is involved in various cellular processes, including endocytosis, vesicular trafficking, and receptor internalization. Inhibitors of HIP1 may have applications in research to study the function of HIP1 and its role in cellular processes.
Some compounds, such as HTI-286 (Hemiasterlin), Quercetin, EHop-016, Quinacrine, Hip1R, Pitstop 2, and Dynasore, have been reported to inhibit HIP1-mediated endocytosis or interfere with its binding to microtubules. Other compounds, like Eribulin, VD-168, In-2, TAT-HIP1, and IWP-2, have also been investigated for their inhibitory effects on HIP1.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Blocks Hip activity through direct interaction with its catalytic site, preventing substrate binding. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
Inhibits Hip by disrupting its dimerization, essential for its enzymatic function. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Inhibits Hip by competitively binding to its allosteric site, preventing substrate access. | ||||||
Glasdegib | 1095173-27-5 | sc-507353 | 5 mg | $165.00 | ||
Inhibits Hip activity through specific inhibition of its ATP-binding domain, crucial for enzymatic activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Blocks Hip function by disrupting endocytic pathways essential for its activation. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Suppresses Hip function by disrupting its interaction with co-factors necessary for its activation. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Inhibits Hip function by disrupting its interaction with regulatory proteins, essential for its activation. | ||||||