HIATL1 Activators
The proposed class of HIATL1 activators encompasses a variety of compounds that interact with and modulate key regulatory processes within cells, leading to potential changes in the expression or activity of HIATL1. These chemical activators operate through distinct mechanisms that involve epigenetic modifications, such as altering DNA methylation or histone acetylation states with agents like 5-Aza-2'-deoxycytidine and Trichostatin A. Such changes in the epigenetic landscape can result in the upregulation of HIATL1 expression by making the genomic DNA surrounding the HIATL1 gene more accessible to transcription factors and the transcriptional machinery.
The activators also include compounds that target intracellular signaling cascades. For instance, Forskolin, by elevating cAMP levels, triggers PKA activation, which can phosphorylate transcription factors, thereby possibly enhancing the transcription of the HIATL1 gene. Hormonal signals, such as those induced by beta-estradiol, result in the activation of specific receptors that function as transcription factors directly influencing gene expression patterns. Additionally, compounds like AICAR, which activates AMPK, have broad effects on cellular metabolism and growth signaling that could indirectly lead to the upregulation of HIATL1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
By inhibiting DNA methyltransferase, this compound can cause demethylation of gene promoters, leading to the transcriptional activation of genes that may have been silenced by methylation, potentially including HIATL1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it leads to increased acetylation of histones, causing chromatin to become more open and accessible to transcription machinery, possibly resulting in enhanced HIATL1 transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Also a histone deacetylase inhibitor, this compound can lead to an open chromatin state and promote the transcription of multiple genes, potentially including HIATL1, by allowing transcription factors better access to DNA. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Acts on retinoic acid receptors, which dimerize and bind to retinoic acid response elements in the promoters of target genes, possibly activating transcription of HIATL1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which activates protein kinase A (PKA) and can lead to the phosphorylation and activation of transcription factors that may enhance HIATL1 gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Interacts with estrogen receptors that, when activated, can function as transcription factors to promote gene expression, potentially upregulating HIATL1. | ||||||
Kinetin | 525-79-1 | sc-207780 sc-207780A | 1 g 5 g | $38.00 $48.00 | ||
It can modulate transcription and potentially stimulate the expression of a broad range of genes, including HIATL1, by affecting transcription factor activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Induces the expression of various genes by affecting transcription factor NRF2, which may upregulate antioxidant response elements and could influence HIATL1 expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, leading to the phosphorylation of downstream targets that can modulate transcription factors and gene expression, possibly increasing HIATL1 expression. | ||||||