HHV-8 activators constitute a specialized chemical class of compounds recognized for their capacity to influence the activation of HHV-8, or Human Herpesvirus 8, also known as Kaposi's Sarcoma-Associated Herpesvirus (KSHV). These activators are designed to interact with the HHV-8 virus or its associated cellular machinery, potentially promoting viral replication and gene expression. At the molecular level, the mechanisms through which HHV-8 activators exert their effects can be multifaceted, and they may involve interactions with specific viral proteins or cellular factors that are critical for the virus's life cycle.
The study of HHV-8 activators is instrumental in advancing our understanding of the molecular intricacies and their interaction with host cells. Researchers in this field primarily focus on elucidating the precise molecular mechanisms by which these compounds impact HHV-8's activation and replication. Understanding the role of HHV-8 activators contributes to our broader knowledge of viral pathogenesis and the complex interplay between viruses and their host cells. Moreover, these compounds serve as valuable tools for scientists seeking to investigate the underlying molecular events that drive HHV-8 infections, ultimately deepening our comprehension of herpesvirus biology and its potential implications in various scientific and biomedical contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A known stimulator of protein kinase C (PKC); induces lytic reactivation of HHV-8. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor; promotes viral gene expression and lytic reactivation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Another histone deacetylase inhibitor; can induce HHV-8 reactivation in cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid that can modulate various gene expressions; potential influence on HHV-8 reactivation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Affects various signaling pathways; could potentially modulate HHV-8 expression or reactivation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor; might have an effect on HHV-8 replication and reactivation. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Immunosuppressant that may influence HHV-8 reactivation, | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Another glucocorticoid; potential to influence HHV-8 latency and reactivation. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Might influence HHV-8 replication or reactivation through hormonal pathways. | ||||||