Heme Oxygenase 2 Activators
The class of Heme Oxygenase 2 (HO-2) activators comprises a diverse range of chemicals that influence the activity of this crucial enzyme involved in heme catabolism. Hemin, Hemin Chloride, and Hematin, direct activators of HO-2, serve as substrates for the enzyme, initiating the breakdown of heme into biliverdin, iron, and carbon monoxide. Cobalt Protoporphyrin (CoPP), a well-established HO-2 activator, induces the enzyme's expression, emphasizing the significance of transcriptional regulation in modulating HO-2 activity. In contrast, Zinc Protoporphyrin (ZnPP) acts as an inhibitor, underlining the specificity of chemical modulation in the context of HO-2.
Beyond direct activators, compounds like Protoporphyrin IX and Quercetin act indirectly, potentially influencing cellular processes or signaling pathways associated with HO-2. The dynamic interplay between these chemicals and HO-2 reflects the intricate regulatory mechanisms governing heme homeostasis. This diverse array of activators offers a nuanced perspective on the modulation of HO-2 and opens avenues for further exploration into the cellular pathways through which these chemicals exert their effects. As researchers delve deeper into understanding the intricacies of HO-2 regulation, these activators serve as invaluable tools, shedding light on the multifaceted roles of HO-2 in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $102.00 $160.00 $326.00 | 9 | |
Hemin, also known as heme or hematin, directly activates Heme Oxygenase 2 (HO-2) by serving as a substrate. Hemin binds to the active site of HO-2, initiating the heme degradation process and promoting HO-2 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, an ion with diverse cellular effects, has been suggested to modulate Heme Oxygenase 2 indirectly. The precise pathways through which lithium influences HO-2 activity warrant further investigation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid compound, has been suggested to influence Heme Oxygenase 2 activity. Its indirect activation of HO-2 may involve multiple cellular pathways, emphasizing the potential pleiotropy of HO-2 regulation. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
β-Naphthoflavone, a synthetic flavonoid, may act as an indirect activator of Heme Oxygenase 2. Its impact on cellular processes or signaling pathways associated with HO-2 warrants further investigation for a comprehensive understanding. | ||||||