HE6 Activators
HE6, also known as GPR64, is a member of the G-protein coupled receptor (GPCR) superfamily and is specifically classified within the adhesion GPCR subgroup. This protein is predominantly expressed in the epididymis, a highly specialized duct within the male reproductive system where sperm maturation occurs. The HE6 receptor is thought to play a crucial role in the regulation of the epididymal environment and in processes essential for sperm maturation and acquisition of motility, which are critical for male fertility.The structure of HE6 includes a long N-terminal extracellular region with several domains that are characteristic of adhesion GPCRs, which facilitate cell-cell and cell-matrix interactions. These interactions are important for maintaining the integrity of the epithelial cell layer in the epididymis and for the establishment of the specialized luminal environment required for sperm development.
The exact physiological ligands and signaling pathways of HE6 are not fully understood, but it is believed that the receptor may be involved in sensing changes in the luminal environment of the epididymis, including pH and ion concentrations, which are important for sperm maturation. Additionally, HE6 may have a role in the immune privilege of the epididymis, protecting sperm from autoimmune responses.Mutations or dysregulation of HE6/GPR64 have been implicated in contributing to certain reproductive disorders, highlighting its importance in male reproductive health.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can modulate the expression of certain genes in male reproductive tissues. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is involved in the differentiation of epithelial tissues and may affect HE6 expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
As a cAMP analog, it can mimic intracellular signaling that may upregulate HE6 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase and increases cAMP, potentially influencing HE6 expression. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
This synthetic estrogen has been shown to affect gene expression in reproductive tissues. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone plays a role in male reproductive health and could impact HE6 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has a role in the regulation of genes and may influence HE6 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is essential for male fertility and may affect HE6 expression in the epididymis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can affect hormone signaling and may influence HE6 expression through its endocrine modulatory effects. | ||||||