HDAC2 Inhibitors
Santa Cruz Biotechnology now offers a broad range of HDAC2 Inhibitors. Histone deacetylase proteins (HDACs) are a class of enzymes that remove acetyl groups (O=C-CH3) from an <ε>-N-acetyl lysine amino acid on a histone, allowing histones to wrap DNA more tightly. The deacetylation of histones is associated with transcriptional silencing. Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptic. HDIs are studied as a treatment for neurodegenerative diseases and have a potential for cancer therapy. HDAC2 Inhibitors offered by Santa Cruz inhibit HDAC2 and, in some cases, other chromatin remodeling and transcription regulation related proteins. View detailed HDAC2 Inhibitor specifications, including HDAC2 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 1 to 10 of 16 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PCI-24781 | 783355-60-2 | sc-364565 sc-364565A | 5 mg 50 mg | $182.00 $1330.00 | 1 | |
PCI-24781 is a potent inhibitor of HDAC2, distinguished by its unique binding affinity that stabilizes the enzyme in an inactive conformation. This compound engages in specific hydrogen bonding and hydrophobic interactions, effectively altering the enzyme's active site dynamics. Its selective action leads to significant modulation of histone modifications, influencing chromatin structure and accessibility, thereby impacting transcriptional regulation and cellular signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a classical HDAC inhibitor that binds to the active site of HDAC2. By inhibiting its activity, TSA can lead to increased acetylation and potentially affect HDAC2 stability or expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a selective HDAC1 and HDAC2 inhibitor. By inhibiting HDAC2 activity, it can modulate gene expression profiles. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
CI 994 is a selective HDAC2 inhibitor characterized by its ability to disrupt the enzyme's catalytic activity through unique molecular interactions. It forms specific electrostatic and van der Waals contacts, which induce conformational changes in the enzyme. This compound's kinetic profile reveals a rapid association and slower dissociation, enhancing its inhibitory potency. By altering histone acetylation patterns, CI 994 influences gene expression and cellular processes at a fundamental level. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is an HDAC inhibitor with selectivity for HDAC1, 2, and 3. It can inhibit HDAC2 activity and potentially its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a pan-HDAC inhibitor used clinically. It inhibits HDAC2 activity and may affect its expression in some cellular contexts. | ||||||
Pimelic Diphenylamide 106 | 937039-45-7 | sc-364589 sc-364589A | 1 mg 5 mg | $41.00 $74.00 | ||
Pimelic Diphenylamide 106 acts as a selective HDAC2 inhibitor, exhibiting a unique binding affinity that stabilizes the enzyme in an inactive conformation. Its distinct molecular interactions involve hydrogen bonding and hydrophobic contacts, which modulate the enzyme's active site dynamics. The compound demonstrates a notable reaction kinetics profile, with a pronounced rate of inhibition that suggests a strong, persistent engagement with HDAC2, ultimately impacting chromatin remodeling and transcriptional regulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is an HDAC inhibitor that can inhibit HDAC2 function, leading to changes in gene expression patterns. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
JNJ-26481585 is a potent HDAC inhibitor that can inhibit HDAC2. Its action might affect HDAC2 stability or expression. | ||||||
PI3K/HDAC Inhibitor | 1339928-25-4 | sc-364584 sc-364584A | 5 mg 10 mg | $340.00 $462.00 | ||
The PI3K/HDAC Inhibitor selectively targets HDAC2, showcasing a unique mechanism of action through its ability to disrupt the enzyme's structural integrity. This compound engages in specific electrostatic interactions and forms a stable complex that alters the conformational landscape of HDAC2. Its kinetic properties reveal a slow off-rate, indicating prolonged inhibition, which can significantly influence cellular signaling pathways and gene expression profiles. | ||||||