HDA5 Inhibitors
Chemical inhibitors of HDA5 function primarily by obstructing the enzyme's ability to deacetylate histone proteins, a key process in the regulation of gene expression within cells. Trichostatin A, Vorinostat, and Panobinostat, for instance, operate by binding to HDA5 and impeding its deacetylase activity. This interaction leads to an accumulation of acetylated histones, which are not able to undergo the normal deacetylation process that HDA5 typically facilitates. Similarly, Belinostat and Romidepsin exert their inhibitory effect by associating with the active site of HDA5, thereby hindering the enzyme's capacity to interact with histones and carry out its function of removing acetyl groups. Chidamide follows the same mechanism, binding to HDA5 and altering its activity, which results in an increase in acetylated histones in the cell.
Moreover, Valproic acid and Sodium butyrate, while having different primary uses, also display HDA5 inhibitory activity by increasing the level of histone acetylation, thereby affecting the chromatin structure and altering the expression of genes regulated by HDA5. SAHA, another name for Vorinostat, binds to HDA5 and blocks the enzyme's deacetylating function, leading to changes in gene expression. Entinostat, Mocetinostat, and Tacedinaline, all of which are HDAC inhibitors, can inhibit HDA5 by binding to its deacetylase domain, thus preventing the enzyme from deacetylating histone proteins. This inhibition results in the persistence of acetylation on histones, which subsequently impacts the transcriptional control that HDA5 normally would exert over its target genes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylase (HDAC), which may lead to an increased acetylation of HDA5, thereby inhibiting its deacetylation function on histones. This prevents HDA5 from contributing to the removal of acetyl groups from histone tails, a key process in the regulation of gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is an HDAC inhibitor that can inhibit HDA5 by blocking its deacetylase activity. This leads to a build-up of acetylated histones, which can alter the expression of genes regulated by HDA5, effectively inhibiting its function in the cell. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat acts as an HDAC inhibitor and can inhibit HDA5 by preventing the deacetylation of histones. This results in the suppression of HDA5's role in chromatin remodeling and gene silencing. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is known to inhibit HDAC activity, therefore it can inhibit HDA5 by stopping the deacetylation process on histones, which in turn affects the chromatin structure and gene expression regulated by HDA5. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide that inhibits HDAC, including HDA5. By binding to the active site of HDA5, it inhibits its deacetylation function, leading to changes in gene expression patterns that HDA5 would normally regulate. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide is an HDAC inhibitor that can inhibit HDA5 by interfering with its enzyme activity, preventing the removal of acetyl groups from histones, and thereby affecting transcriptional regulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, though primarily used for other indications, possesses HDAC inhibitory activity and can inhibit HDA5 by preventing deacetylation of histones, thus altering gene expression patterns that HDA5 controls. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor and can inhibit HDA5 by increasing histone acetylation, which in turn can lead to gene expression changes in the cell. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a selective HDAC inhibitor that can inhibit HDA5 by binding to its deacetylase domain, thus preventing the deacetylation of histone proteins and impacting gene expression that HDA5 would typically influence. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is an HDAC inhibitor that can inhibit HDA5 by preventing the enzyme from removing acetyl groups from histones, thereby influencing the transcriptional control exerted by HDA5 on its target genes. | ||||||