Romidepsin CAS: 128517-07-7
MF: C24H36N4O6S2
MW: 540.70
An HDAC1, HDAC2, HDAC4, and HDAC6 inhibitor.

Romidepsin (CAS 128517-07-7)

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Nombres Alternativos: Depsipeptide; Istodax; Chromadax
Solicitud: Romidepsin is an HDAC1, HDAC2, HDAC4, and HDAC6 inhibitor
Número de CAS: 128517-07-7
Pureza: ≥98%
Peso Molecular: 540.70
Fórmula Molecular: C24H36N4O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein. In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, Romidepsin treatment up-regulates tumor death receptors, and potentiates natural killer (NK)-mediated tumor killing. Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines.

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (10 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and chloroform.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
219-224° C
Punto de ebullición :
~942.8° C at 760 mmHg (Predicted)
Densidad :
~1.2 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.53 (Predicted)
IC50 :
HDAC1: IC50 = 0.2 nM (human); HDAC2: IC50 = 1 nM (human); Histone deacetylase 3/Nuclear receptor corepressor 2 : IC50 = 3 nM (human); HDAC6: IC50 = 0.2 µM (human); HDAC4: IC50 = 0.51 µM (human)
Valores de pK :
pKa: 11.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
YV9399000
PubChem CID :
5352062
Número MDL :
MFCD18433404
SMILES :
C/C=C1/C(=O)N[[email protected]](C(=O)O[[email protected]]2CC(=O)N[[email protected]@H](C(=O)N[[email protected]](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

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