Sodium Butyrate CAS: 156-54-7
MF: C4H7O2Na
MW: 110.09

Sodium Butyrate (CAS 156-54-7)

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Sodium Butyrate is rated 5.0 out of 5 by 2.
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Nombres Alternativos: Sodium Butyrate also known as Butyric acid sodium salt; Butanoicacidsodiumsalt butyratesodium; sodiumpropanecarboxylate
Solicitud: Sodium Butyrate is an HDAC inhibitor, apoptosis inducer and can induce differentiation and gene expression and also prevent cell proliferation
Número de CAS: 156-54-7
Pureza: ≥98%
Peso Molecular: 110.09
Fórmula Molecular: C4H7O2Na
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). Sodium Butyrate has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally Sodium Butyrate demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.


References

1. Sealy, L., et al., 1978. The effect of sodium butyrate on histone modification. Cell. 14(1): 115-21. PMID: 667928

2. Davie, James R., et al., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition. 133(7 Suppl): 2485S-2493S. PMID: 12840228

3. Joseph, Jeena., et al., 2004. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 23(37): 6304-15. PMID: 15318170

4. Sekhavat, Anoushe., et al., 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochemistry and cell biology = Biochimie et biologie cellulaire. 85(6): 751-8. PMID: 18059533

Estado de Materia :
Solid
Solubilidad :
Soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7.2 (~10 mg/ml). Insoluble in ether.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
250-253° C (lit.)
IC50 :
Histone deacetylase 7: IC50 = 140 µM (human); Histone deacetylase 8: IC50 = 140 µM (human); Histone deacetylase 1: IC50 = 140 µM (human)
Datos Ki :
Carbonic anhydrase: Ki= 26.9 µM (Candida albicans ); Carbonic anhydrase I: Ki= 511 µM (human)
Valores de pK :
pKa: 4.82
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
1
RTECS :
ET6400000
PubChem CID :
5222465
Número MDL :
MFCD00002816
Número EC :
205-857-6
Registro Beilstein :
3629439
SMILES :
CCCC(=O)[O-].[Na+]

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PMID: # 29235036  Ho, CF.|Bon, CP.|Ng, YK.|Herr, DR.|Wu, JS.|Lin, TN.|Ong, WY.| et al. 2018. Neurochem. Res. 43: 540-555.

PMID: # 25342559  Yang, Y. et al. 2014. Cell Res. 24: 1342-53.

PMID: # 17967882  Pesavento, JJ. et al. 2008. Mol. Cell. Biol. 28: 468-486.

PMID: # 17881451  Neumann, DM. et al. 2007. J. Virol. 81: 13248-13253.

PMID: # 16699007  Lu, F. et al. 2006. J. Virol. 80: 5273-5282.

PMID: # 12654818  Scaife, H. et al. 2003. Infect. Immun. 71: 1995-2001.

PMID: # 11884567  Chiou, CJ. et al. 2002. J. Virol. 76: 3421-3439.

PMID: # 10639456  Gerçeker, AA. et al. 2000. Infect. Immun. 68: 861-870.

PMID: # 9971760  Gasmi, M. et al. 1999. J. Virol. 73: 1828-1834.

PMID: # 30616788  Oral Oncol. 88: 160-167.

Citaciones 1 a 10 de un total de 12
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