HCP1 (SLC46A1) Inhibitors
HCP1 (SLC46A1) inhibitors are a class of chemical compounds specifically designed to target and interact with the HCP1 protein, also known as the proton-coupled folate transporter (PCFT) encoded by the SLC46A1 gene. HCP1, primarily expressed in the small intestine and involved in folate uptake, plays a crucial role in mediating the transport of folate and other structurally related molecules across cell membranes. Inhibitors of HCP1 function by interfering with the normal transport mechanism of folate and its derivatives, thereby modulating the cellular uptake of these essential compounds.
HCP1 (SLC46A1) signaling primarily involves the regulation of folate transport across cell membranes. HCP1, also known as the proton-coupled folate transporter (PCFT), is a protein encoded by the SLC46A1 gene. It functions as a transporter for folates and related compounds, playing a crucial role in folate homeostasis within the body. The signaling related to HCP1 primarily revolves around the transport of folates. When the body requires folates, HCP1 is responsible for facilitating their uptake into cells, particularly in the small intestine.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a chemotherapeutic agent that is structurally similar to folate and can competitively inhibit SLC46A1, reducing the transport of folates into cells. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is an agent in research used to gout. It has been shown to indirectly inhibit SLC46A1 by altering the pH of the extracellular environment, which affects the transporter's activity. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine is a drug. It can inhibit SLC46A1 by competitively blocking the transport of folates, leading to reduced folate uptake in cells. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $67.00 $161.00 $255.00 $721.00 $3401.00 | 4 | |
Trimethoprim is an antibiotic that can inhibit dihydrofolate reductase, an enzyme involved in the synthesis of tetrahydrofolate. Inhibition of this enzyme indirectly affects the folate transport via SLC46A1. | ||||||
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid | 137281-23-3 | sc-479733 | 250 mg | $330.00 | 1 | |
Pemetrexed is a drug that inhibits multiple folate-dependent enzymes. Its action indirectly impacts SLC46A1 by reducing the cellular demand for folates. | ||||||
Folinic acid calcium salt | 1492-18-8 | sc-252837 sc-252837A | 100 mg 500 mg | $94.00 $375.00 | 3 | |
Leucovorin is an agent in research often used in combination with methotrexate to rescue normal cells from the toxic effects of methotrexate. It can also inhibit SLC46A1 by competitively blocking the transport of folates. | ||||||
Raltitrexed | 112887-68-0 | sc-219933 | 10 mg | $146.00 | ||
Raltitrexed is an antimetabolite drug used in cancer research. It inhibits thymidylate synthase, an enzyme involved in DNA synthesis, indirectly affecting the folate transport via SLC46A1. | ||||||