Date published: 2026-5-30

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Guanylate Cyclase (GUCA) Inhibitors

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-NG-Nitroarginine Methyl Ester (L-NAME)

51298-62-5sc-200333
sc-200333A
sc-200333B
1 g
5 g
25 g
$48.00
$107.00
$328.00
45
(1)

Inhibits nitric oxide synthase (NOS), which can indirectly affect guanylate cyclase activity, and hence Guanylate Cyclase Activator (GUCA) function.

ODQ

41443-28-1sc-200325
sc-200325A
10 mg
50 mg
$78.00
$222.00
13
(1)

A soluble guanylate cyclase inhibitor. By inhibiting guanylate cyclase, ODQ can indirectly modulate the actions of Guanylate Cyclase Activator (GUCA).

Riociguat

625115-55-1sc-476845
5 mg
$300.00
(0)

It is a direct stimulator of soluble guanylate cyclase (sGC), used for pulmonary hypertension. It can provide insights into sGC signaling pathways.

Methylene blue

61-73-4sc-215381B
sc-215381
sc-215381A
25 g
100 g
500 g
$43.00
$104.00
$328.00
3
(1)

Acts on guanylate cyclase, reducing its activity and hence indirectly influencing Guanylate Cyclase Activator (GUCA).

Aceclofenac

89796-99-6sc-217557
10 mg
$98.00
(0)

Inhibits guanylate cyclase activity, thereby having potential indirect effects on Guanylate Cyclase Activator (GUCA) function.

KT5823

126643-37-6sc-3534
sc-3534A
sc-3534B
100 µg
1 mg
5 mg
$182.00
$1228.00
$4895.00
21
(1)

Protein kinase G inhibitor. As Guanylate Cyclase Activator (GUCA)'s role in guanylate cyclase activation can influence cGMP and PKG activity, inhibiting PKG can indirectly influence Guanylate Cyclase Activator (GUCA)-associated signaling.

Vinpocetine

42971-09-5sc-201204
sc-201204A
sc-201204B
20 mg
100 mg
15 g
$55.00
$214.00
$2400.00
4
(1)

Acts as a PDE1 inhibitor, preventing the breakdown of cGMP. This can influence the balance of cGMP in the cell and indirectly modulate Guanylate Cyclase Activator (GUCA)'s function.

Zaprinast (M&B 22948)

37762-06-4sc-201206
sc-201206A
25 mg
100 mg
$105.00
$250.00
8
(2)

A PDE5 inhibitor which affects cGMP levels. By modulating cGMP concentrations, Zaprinast can indirectly influence Guanylate Cyclase Activator (GUCA)-associated functions.

Tadalafil

171596-29-5sc-208412
50 mg
$180.00
13
(2)

PDE5 inhibitor affecting cGMP concentrations. This alteration in cGMP can indirectly have effects on Guanylate Cyclase Activator (GUCA)'s role in the pathway.

Vardenafil

224785-90-4sc-362054
sc-362054A
sc-362054B
100 mg
1 g
50 g
$526.00
$735.00
$16653.00
7
(1)

Another PDE5 inhibitor impacting cGMP levels. By doing so, it can indirectly modulate the activities where Guanylate Cyclase Activator (GUCA) is involved.