GTSE-1 Activators
G2 and S phase-expressed-1 (GTSE1) is a protein in humans that is encoded by the GTSE1 gene. As the name suggests, GTSE1 is expressed during the G2 and S phases of the cell cycle, and it plays significant roles in cell cycle regulation, particularly in relation to the G2/M transition.GTSE1 interacts with several other proteins, most notably p53, a key tumor suppressor protein. Under normal conditions, GTSE1 binds to p53 and facilitates its nuclear export, thereby inhibiting p53's ability to induce cell cycle arrest and apoptosis. However, upon DNA damage, GTSE1 is phosphorylated and its interaction with p53 is disrupted, allowing p53 to exert its tumor suppressor functions.
In addition to its interaction with p53, GTSE1 also binds to microtubules and is involved in regulating their stability. This is important for proper chromosome segregation during cell division, and aberrant regulation can lead to aneuploidy, a condition associated with cancer.From a perspective, GTSE1 has been implicated in several types of cancer. High levels of GTSE1 expression have been associated with poor prognosis in cancers such as breast cancer, hepatocellular carcinoma, and gastric cancer. Its role in promoting cell proliferation and inhibiting p53 suggests that it may contribute to tumor growth and resistance to therapy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and can indirectly influence GTSE1 activity by affecting cell cycle dynamics. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Disrupts microtubule formation, potentially altering cell cycle progression and GTSE1 activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent, can affect cell cycle progression and potentially GTSE1 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits topoisomerase II, influencing DNA replication and cell cycle, thereby indirectly affecting GTSE1. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Causes DNA damage, potentially influencing GTSE1 through cell cycle checkpoint mechanisms. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline antibiotic that intercalates DNA, indirectly affecting cell cycle and GTSE1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog that disrupts nucleotide synthesis, potentially impacting GTSE1 activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Inhibits dihydrofolate reductase, affecting DNA synthesis and potentially GTSE1. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Induces DNA strand breaks, possibly influencing GTSE1 through cell cycle regulation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, impacting DNA synthesis and potentially affecting GTSE1. | ||||||