GSTT3 Activators

Glutathione S-transferase theta 1 (GSTT1) is an enzyme encoded by the GSTT1 gene in humans. It belongs to the glutathione S-transferase (GST) family, a group of enzymes that play crucial roles in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione.GSTT1, like other members of the GST family, is involved in the biotransformation of a wide variety of xenobiotics and endogenous compounds. These include carcinogens, drugs, environmental toxins, and products of oxidative stress, thereby protecting cells from damages that could lead to diseases such as cancer.The structure of GSTT1 is characterized by an active site that binds to glutathione, allowing it to react with suitable electrophilic substrates. The protein is dimeric, meaning it consists of two identical subunits. This dimeric structure contributes to the enzyme's functionality and substrate specificity.

There's a significant genetic variation in the GSTT1 gene among the population, with a common deletion polymorphism resulting in a lack of the GSTT1 enzyme in some individuals. This absence has been associated with an increased susceptibility to several types of cancers due to the reduced capacity to detoxify carcinogenic compounds.Furthermore, GSTT1's role in drug metabolism can influence individual responses, impacting the efficacy and toxicity of certain agents.In conclusion, GSTT1 is a critical detoxification enzyme, integral to the metabolism of various harmful compounds. Its genetic polymorphisms can significantly influence an individual's susceptibility to diseases and response, underscoring the protein's relevance in human health and disease.