GSTK1 Inhibitors
GSTK1 inhibitors belong to a specific chemical class known for their ability to selectively target and inhibit the enzyme Glutathione S-transferase kappa 1 (GSTK1). These inhibitors are designed to interact with the active site of the GSTK1 enzyme, preventing it from catalyzing its usual biochemical reactions. GSTK1 is a member of the Glutathione S-transferase (GST) superfamily of enzymes, which play a crucial role in cellular detoxification and protection against oxidative stress.
By inhibiting GSTK1, these compounds may modulate cellular responses to various endogenous and exogenous compounds that are substrates of the enzyme. The structural design and chemical properties of GSTK1 inhibitors are finely tuned to achieve high specificity, reducing the likelihood of cross-reactivity with other GST isoforms or unrelated enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Hydroxynonenal | 75899-68-2 | sc-202019 sc-202019A sc-202019B | 1 mg 10 mg 50 mg | $118.00 $655.00 $2774.00 | 25 | |
An endogenous aldehyde product of lipid peroxidation, which acts as a GSTK1 inhibitor. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Ethacrynic acid (CAS 58-54-8) is a potent inhibitor of the glutathione S-transferase kappa 1 (GSTK1) protein. It functions by covalently binding to the cysteine residues within GSTK1, disrupting the enzyme′s activity and impacting cellular detoxification pathways. This inhibition is valuable in research exploring GSTK1-related biochemical mechanisms, including studies on protein-ligand interactions and enzyme regulation. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Originally identified as an anti-parasitic compound, halofuginone has been shown to inhibit GSTK1 and exhibits properties. | ||||||
PGA2 (Prostaglandin A2) | 13345-50-1 | sc-201215 sc-201215A | 1 mg 10 mg | $214.00 $418.00 | 2 | |
A natural product found in prostaglandin metabolism that has been identified as a GSTK1 inhibitor. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
A phytochemical found in cruciferous vegetables that has been studied for its anti-cancer effects through GSTK1 inhibition. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A derivative of curcumin, the active compound in turmeric, which has been shown to inhibit GSTK1. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $80.00 | ||
A compound found in garlic that has been reported to inhibit GSTK1 activity. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Originally developed as an antioxidant, ebselen has been identified as a GSTK1 inhibitor. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $75.00 $221.00 | 6 | |
A phenolic diterpene found in rosemary that has been shown to inhibit GSTK1. | ||||||