GSH-1 Activators
Chemicals that serve as activators for glutathione synthesis or function are primarily focused on providing precursors for glutathione synthesis or enhancing the activity of enzymes involved in its metabolic pathway. Glutathione (GSH) plays a crucial role in protecting cells against oxidative stress, and its synthesis is vital for maintaining cellular health and resilience. N-Acetylcysteine (NAC) and S-Adenosylmethionine (SAMe) are notable for their roles in increasing intracellular glutathione levels. NAC provides cysteine, a limiting substrate for glutathione synthesis, while SAMe contributes to methionine metabolism, which is closely linked to glutathione production.
Antioxidants such as Alpha-Lipoic Acid, Vitamin C, and Vitamin E are important in maintaining the glutathione redox cycle. Vitamin C, in particular, can help regenerate glutathione in its reduced form, which is crucial for its antioxidant function. Vitamin E works synergistically with glutathione to protect cells from oxidative damage. Micronutrients like Selenium, Riboflavin, and Zinc play supporting roles in the glutathione cycle. Selenium is a cofactor for glutathione peroxidase, an important enzyme that uses glutathione to detoxify harmful peroxides. Riboflavin is essential for the glutathione redox cycle, helping in the regeneration of glutathione. Lastly, Silymarin, a compound found in milk thistle, has been shown to elevate glutathione levels, further supporting cellular antioxidant defenses. The focus on these activators highlights the importance of various nutrients and compounds in supporting glutathione synthesis and function. By enhancing glutathione levels and activity, these chemicals play a significant role in maintaining cellular health, particularly in conditions of oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine is a precursor to the amino acid cysteine, which is essential for the synthesis of glutathione, a major cellular antioxidant. NAC elevates cysteine availability, thereby boosting glutathione synthesis, especially under conditions of oxidative stress. It also acts directly as a scavenger of free radicals and reactive oxygen species, providing additional antioxidative benefits. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
S-Adenosylmethionine, a compound involved in methionine metabolism, plays a critical role in the methylation processes within the cell. It contributes to the synthesis of cysteine, a glutathione precursor, by donating methyl groups necessary for the conversion of homocysteine to methionine and subsequently to cysteine. This process is crucial in maintaining adequate glutathione levels, particularly in the liver. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid is a potent antioxidant that is both water and fat-soluble, enabling it to function in various cellular environments. It enhances the synthesis of glutathione by increasing cysteine uptake in cells and also plays a role in regenerating other antioxidants, including glutathione itself. Its ability to chelate metal ions also contributes to its antioxidative capacity. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine is an essential amino acid and a critical precursor in the glutathione synthesis pathway. It is first converted to S-Adenosylmethionine (SAMe), which then contributes to the transsulfuration pathway leading to cysteine production. Methionine supplementation can thus support glutathione synthesis by ensuring the availability of its precursor cysteine. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is a trace element that is a cofactor for the enzyme glutathione peroxidase. This enzyme uses glutathione to reduce harmful peroxides, converting them into water and alcohol, thus protecting cells from oxidative damage. Adequate selenium levels are essential for the proper functioning of this enzyme, thereby supporting the antioxidant role of glutathione. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
L-Ascorbic acid is a well-known antioxidant that also helps to regenerate glutathione in its reduced form. It reduces oxidized glutathione (GSSG) back to its reduced form (GSH), maintaining the active state of glutathione for antioxidative defense. This synergistic interaction enhances the overall antioxidant capacity of cells. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Tocopherol, primarily functioning as a lipid-soluble antioxidant, works in tandem with glutathione to protect cell membranes from oxidative damage. It can be regenerated from its oxidized form by glutathione, thereby maintaining its antioxidant function. This interplay enhances cellular protection against lipid peroxidation and oxidative stress. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin, or Vitamin B2, is essential for the glutathione redox cycle. It is a component of the enzyme glutathione reductase, which regenerates reduced glutathione from its oxidized form. Adequate riboflavin is crucial for maintaining the efficacy of this cycle, thus supporting cellular antioxidant defenses. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential trace element that influences several aspects of cellular metabolism, including the maintenance of glutathione levels. It is known to protect the sulfhydryl groups on proteins and glutathione, thereby preserving their structure and function. Zinc deficiency can lead to decreased levels of glutathione, highlighting its role in glutathione metabolism. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine, one of the three amino acids that constitute glutathione, is essential for its synthesis. It binds with glutamate and cysteine to form glutathione, playing a direct role in maintaining adequate glutathione levels in cells. Glycine supplementation can support glutathione synthesis, particularly under conditions where its demand is increased. | ||||||