GS1 Inhibitors
GS1 inhibitors encompass compounds that can interfere with the activity of pseudouridine 5'-phosphatase either directly by binding to the active site of the enzyme or indirectly by affecting associated metabolic or signaling pathways. These inhibitors are diverse in structure and function, ranging from nucleotides, like ATP which competes with the enzyme's natural substrate, to broad-spectrum inhibitors which mimic the transition state of phosphate esters or compete with phosphate groups. GS1 inhibitors can also have an indirect effect by their general action on phosphatases.
GS1 inhibitors act by disrupting signaling pathways; for instance inhibition of the inositol phosphate pathway can have downstream effects on GS1 activity. These inhibtors affect serine/threonine phosphatases by altering phosphoprotein dynamics, thereby indirectly modulating the function of GS1. Similarly, they inhibit protein phosphatases and thus could alter GS1 activity. GS1 inhibitors potentially affect phosphatase activities by modulating the availability or reactivity of phosphate groups.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
High concentrations of ATP can compete with pseudouridine for the active site of GS1, potentially reducing its catalytic efficiency. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium Fluoride is an inhibitor of phosphatases; although non-specific, it can reduce the activity of GS1 by inhibiting its phosphatase activity. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $114.00 $466.00 $693.00 | 1 | |
As an amino acid, it may impact protein synthesis and thereby indirectly affect the levels of GS1 if it alters the translation of proteins involved in the pathway. | ||||||
Sodium metavanadate | 13718-26-8 | sc-251034 sc-251034A | 5 g 25 g | $32.00 $84.00 | 3 | |
Sodium metavanadate is a general inhibitor of phosphatases and may inhibit GS1 by mimicking the transition state of phosphate esters. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
Alendronate is a bisphosphonate that can inhibit various phosphatases; it may indirectly inhibit GS1 activity through its action on similar enzymes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits various enzymes in the inositol phosphate signaling pathway and can indirectly affect phosphatase activity, including that of GS1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of serine/threonine phosphatases, and while GS1 is not directly targeted, there may be an indirect effect on its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a strong inhibitor of protein phosphatases PP1 and PP2A; its effect on GS1 could be indirect through the inhibition of regulatory phosphatases. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is an inhibitor of protein phosphatases; it might indirectly inhibit GS1 by affecting related phosphatase activities. | ||||||