GRIN2 Activators
Direct activators like Glutamate and Glycine bind to their respective sites on the NMDA receptor, initiating the ion channel opening and signaling. D-serine, acting as a co-agonist, enhances this activation process. Spermine, through its polyamine action, potentiates the receptor's response, further influencing GRIN2 activity.
Other compounds like Magnesium and Zinc have dual roles, acting as modulators under specific conditions, reflecting the nuanced regulation of NMDA receptors. Ifenprodil and 7-Chlorokynurenic acid provide targeted modulation, specifically influencing GRIN2-containing receptors and their associated signaling pathways. In contrast, compounds like Memantine and Ketamine, known for their antagonistic properties, play a role in modulating receptor activity by reducing overactivation, thus maintaining a balance in GRIN2-mediated signaling. Pregnenolone sulfate, as a neurosteroid, adds another layer of modulation through its allosteric effects.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
The primary excitatory neurotransmitter in the brain, directly activates NMDA receptors by binding to the glutamate recognition site on the GRIN2 subunit, initiating ion channel opening and neuronal signaling. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
A co-agonist for NMDA receptors, binds to a distinct site on the receptor complex, essential for receptor activation, facilitating the action of glutamate on GRIN2 subunits. | ||||||
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $43.00 $128.00 $204.00 | ||
Acts similarly to glycine as a co-agonist at NMDA receptors, binding to the glycine modulatory site and enhancing NMDA receptor-mediated signaling involving GRIN2. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
A polyamine that can potentiate NMDA receptor activity by binding to sites within the channel or at allosteric sites, influencing the GRIN2 subunit's function. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
An endogenous neurosteroid that can modulate NMDA receptor activity, influencing GRIN2 subunit function through allosteric modulation. | ||||||