GPx-2 Activators
GPx-2, shorthand for Glutathione Peroxidase 2, is one of the selenoproteins in the family of glutathione peroxidases. This family is characterized by the presence of selenium, a trace element, as a crucial component in their active site. GPx-2, like its counterparts, plays a significant role in the detoxification processes within cells by catalyzing the reduction of hydrogen peroxide and organic hydroperoxides to water and corresponding alcohols, respectively. This action prevents potential damage from reactive oxygen species, which can lead to oxidative stress within cells. Given the importance of this enzymatic function, the modulation and upregulation of GPx-2 activity are of interest, and this is where GPx-2 activators come into play.
GPx-2 activators belong to a chemical class that can elevate or stimulate the activity of the GPx-2 enzyme. The exact mechanisms through which these activators function can vary. Some might directly interact with the enzyme, enhancing its binding to substrates or facilitating its conformational changes necessary for enzymatic actions. Others could increase the expression of GPx-2 at the transcriptional or translational levels. The chemical structures of these activators might be diverse, but their commonality lies in their ability to boost GPx-2 activity. Understanding the molecular interactions and the pathways influenced by these activators can be invaluable in the broader context of cellular biochemistry and the intricate balance of oxidative and antioxidative mechanisms within organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
BHA is an antioxidant often used as a food additive. It has been shown to activate various antioxidant defense systems, including the induction of GPx-2, in response to oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane can upregulate antioxidant enzymes. GPx-2 induction is part of its mechanism in providing cellular defense against reactive oxygen species. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, possesses antioxidant properties. Studies have indicated its potential in increasing GPx-2 expression, suggesting a role in oxidative stress protection. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in grapes and red wine, resveratrol has been shown to induce antioxidant enzymes, including GPx-2, thus offering protection against oxidative stress. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $80.00 | ||
DADS is a compound found in garlic. It has been studied for its ability to upregulate GPx-2 and other antioxidant enzymes, pointing to its potential role in oxidative stress defense. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Found in berries and nuts, ellagic acid has demonstrated potential in inducing GPx-2 expression, thus playing a part in cellular antioxidant defense mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in fruits and vegetables. Its potential induction of GPx-2 underscores its role in protection against oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major component of green tea, EGCG has been observed to upregulate GPx-2, suggesting its role in counteracting oxidative damage in cells. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Found in many plant sources, caffeic acid has antioxidant properties and can potentially induce GPx-2 expression, offering protection against oxidative damage. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a soy isoflavone, genistein has been studied for its potential in upregulating GPx-2, underscoring its protective role against oxidative stress. | ||||||