GPR175 Activators
GPR175 Activators can be divided into several categories. The first group includes Anandamide and Cannabidiol. These cannabinoids can enhance GPR175 activation via their interaction with G-protein coupled receptors (GPCRs), thereby amplifying GPCR signaling events. Anandamide and Cannabidiol stimulate cannabinoid receptors, which share signaling pathways with GPR175, leading to enhanced GPR175 activation via G-protein mediated signaling. Similarly, Capsaicin, a vanilloid compound that acts as a ligand for transient receptor potential vanilloid 1 (TRPV1), can trigger GPCR activation and potentially enhance GPR175 activity through G-protein mediated signaling events.
Another group of GPR175 activators includes Resveratrol and Curcumin. Resveratrol, a polyphenolic compound, activates sirtuins, which can affect the activity of GPCRs, thereby enhancing the functional activity of GPR175. Likewise, Curcumin, another polyphenolic compound, can enhance GPR175 activation by affecting the G-protein mediated signaling pathways that GPR175 is directly involved in. Forskolin, Quinidine, Epinephrine, Dopamine, Acetylcholine, L-Arginine, and Sildenafil form another category of GPR175 activators. These compounds act on different targets, but ultimately converge on GPCR signaling pathways, enhancing GPR175 function. For example, Forskolin directly activates adenylyl cyclase, leading to an increase in intracellular cAMP levels and subsequent enhancement of GPR175 activity. Similarly, L-Arginine and Sildenafil enhance GPR175 function by manipulating cGMP levels, a pathway in which GPR175 is known to be involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a vanilloid compound that acts as a ligand for transient receptor potential vanilloid 1 (TRPV1). TRPV1 activation can trigger GPCR activation, potentially enhancing GPR175 activity through the downstream activation of G-protein mediated signaling events. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound known to activate sirtuins. Sirtuins can affect the activity of GPCRs, thereby enhancing the functional activity of GPR175 through the modulation of G-protein mediated signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound that can affect various cellular targets, including GPCRs. Therefore, Curcumin can enhance GPR175 activation by affecting G-protein mediated signaling pathways that GPR175 is directly involved in. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a compound from the plant Coleus forskohlii that directly activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. As GPR175 is a GPCR, increased cAMP levels can enhance its functional activity through the cAMP-dependent signaling pathway. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine is a known blocker of voltage-gated K+ channels and can influence GPCR function. By altering the membrane potential, Quinidine can impact the signaling events that lead to GPR175 activation, specifically through the modulation of G-protein signaling pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is an adrenergic receptor agonist that can stimulate the production of cAMP. Elevations in cAMP levels can lead to the functional activation of GPCRs like GPR175 through the cAMP-dependent signaling pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that activates dopamine receptors, which are GPCRs. Dopamine can enhance GPR175 function by activating G-protein mediated signaling pathways that GPR175 is directly involved in. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase (NOS), which produces nitric oxide (NO). NO can activate guanylate cyclase, leading to increased cGMP levels. The elevated cGMP levels can enhance GPR175 function because GPR175 is involved in cGMP-dependent signaling pathways. | ||||||