GPR107 Activators
GPR107 activators are compounds that indirectly influence the activity of GPR107 through the modulation of intracellular signaling cascades. These activators do not bind to GPR107 directly but instead, they can affect various regulators of GPCR signaling, such as cAMP levels, G protein activity, or intracellular calcium concentrations. Forskolin and IBMX, for instance, function to elevate intracellular cAMP, which is a common second messenger involved in the regulation of GPCRs. By increasing cAMP, these compounds can modulate the signaling environment in which GPR107 operates, potentially leading to its activation.
Similarly, toxins like cholera toxin target G proteins, and compounds like adenosine affect purinergic receptors, which are known to have broad effects on GPCR signaling. Increasing intracellular calcium with agents like A23187 or activating protein kinase C with PMA are other strategies that can modify signaling pathways in cells. Phosphodiesterase inhibitors such as zaprinast, rolipram, and BAY 60-7550 prevent the breakdown of cAMP, thereby amplifying the pathways that rely on this molecule.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Adenylyl cyclase activator that increases intracellular cAMP levels, which can modulate GPCR activity including potentially GPR107 through cAMP-dependent signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases that prevents cAMP degradation, potentially enhancing signaling pathways that might indirectly activate GPR107. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
As a purinergic receptor agonist, it can modulate GPCR activity through purinergic signaling pathways that may intersect with GPR107 regulatory mechanisms. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
G protein activator that can mimic GPCR activation, possibly impacting GPR107 function through altered G protein signaling. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
A manganese chloride compound that can act as a G protein activator, thereby potentially influencing GPR107 activity indirectly. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium levels, which could modulate GPCR signaling pathways including those associated with GPR107. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator that modulates intracellular signaling pathways, potentially influencing GPCR activity, including GPR107. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Phosphodiesterase inhibitor which increases cAMP by preventing its breakdown, could enhance signaling pathways that indirectly activate GPR107. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective phosphodiesterase-4 inhibitor, increases cAMP in cells, which might lead to changes in GPCR-mediated signaling affecting GPR107. | ||||||