GPR10 Activators
Ligands like cannabidiol, PROGLN and physalaemin directly stimulate GPR10 receptor signaling through orthosteric interactions. Neuropeptides vasopressin and oxytocin activate compensatory mechanisms in GPR10 as a result of coordinated G protein coupling. Other molecules like palmitoylethanolamide and L-DOPA enhance GPR10 expression and functional levels via upstream transcriptional or receptor crosstalk events.
Capsaicin demonstrates how GPR10 modulates the activity of binding partners like TRPV1 channels, and how targeting such proteins can produce indirect GPR10 responses. Allosteric regulators pregnenolone and inverse agonists AM630 and diphenhydramine carefully manipulate GPR10 functionality at receptor complexes or relieve tonic inhibition to optimize downstream signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AM-630 | 164178-33-0 | sc-200365B sc-200365 sc-200365A sc-200365C | 5 mg 10 mg 50 mg 100 mg | $78.00 $166.00 $634.00 $869.00 | 8 | |
AM630 is a CB2 receptor antagonist. GPR10 receptor activity is under tonic inhibition by CB2 receptor signaling in some tissues. By blocking this inhibition, AM630 can relieve repression of GPR10 and indirectly enhance its functional output. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $260.00 $1040.00 | 1 | |
Vasopressin engages V1a receptors which couple through Gq proteins. GPR10 couples to Gi/o and cross-talk exists between Gi/o and Gq pathways. Vasopressin activates compensatory mechanisms in GPR10 signaling through this G protein interaction network. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Similar to vasopressin, oxytocin activates its receptor (also V1a coupled) to indirectly modulate GPR10 activity through coordinated G protein networks. Both neuropeptides precisely enhance GPR10 function through physiology-based activation of these coupled pathways. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $87.00 $148.00 $347.00 $1122.00 | ||
Pregnenolone acts as an allosteric modulator of several GPCRs including cannabinoid receptors that regulate GPR10. It fine-tunes GPR10 functional selectivity at receptor complexes to optimize downstream signaling outputs. | ||||||
Levodopa | 59-92-7 | sc-205372 sc-205372A | 5 g 25 g | $54.00 $171.00 | 9 | |
L-DOPA enhances dopamine neurotransmission. GPR10 expression is regulated through dopamine D2 receptor coupling and cAMP pathways. L-DOPA treatment activates these mechanisms to augment GPR10 functional levels. | ||||||
Physalaemin | 2507-24-6 | sc-499389 | 1 mg | $97.00 | ||
Physalaemin is a compound from frog skin that activates GPR10. It directly stimulates GPR10 to trigger downstream signaling events like calcium mobilization and mitogen activation. | ||||||
Sarafotoxin 6c | 121695-87-2 | sc-397331 sc-397331A sc-397331B sc-397331C | 100 µg 500 µg 1 mg 2.5 mg | $423.00 $816.00 $1533.00 $2550.00 | 1 | |
Sarafotoxin S6c engages GPR10 as a selective receptor agonist. This results in enhanced GPR10 signaling through canonical receptor:ligand interactions that stimulate intracellular effectors. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 channels while GPR10 modulates TRPV1 function. Capsaicin treatment stimulates a coordinate response between these coupled systems to indirectly enhance GPR10 activity. | ||||||
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $52.00 $84.00 $124.00 | 4 | |
Diphenhydramine is an H1 receptor inverse agonist. GPR10 signals through H1 receptors and their pathways in some tissues. Diphenhydramine relieves tonic repression of GPR10 by H1 receptors, heightening its functional responsiveness. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $80.00 $243.00 $2091.00 $3339.00 $16657.00 | ||
Palmitoylethanolamide activates PPAR-α which regulates GPR10. It boosts GPR10 function through upstream transcriptional control mediated by PPAR-α receptor stimulation. | ||||||